Charles Swanton, Julian Downward Cancer Cell

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Presentation transcript:

Unraveling the Complexity of Endocrine Resistance in Breast Cancer by Functional Genomics Charles Swanton, Julian Downward Cancer Cell Volume 13, Issue 2, Pages 83-85 (February 2008) DOI: 10.1016/j.ccr.2008.01.021 Copyright © 2008 Elsevier Inc. Terms and Conditions

Figure 1 Endocrine Resistance Mediated by Signal Transduction Cascades Tamoxifen induces a G1 cell cycle arrest. Activation of signal transduction molecules associated with resistance to endocrine therapies (red) or sensitivity (blue) affects progression through the G1/S phase of the cell cycle. CDK10 loss drives ERK pathway activity through transcriptional upregulation by ETS2 of c-Raf-1. ETS2 also induces senescence through p16INK4A. STIs targeting this pathway (black) may enhance endocrine response. Cancer Cell 2008 13, 83-85DOI: (10.1016/j.ccr.2008.01.021) Copyright © 2008 Elsevier Inc. Terms and Conditions