Table 1. Cases of reported, confirmed cases of invasive pneumococcal disease: number and rate per 100 000 population, EU/EEA, 2010–2014 Country 2010 2011 2012 2013 2014 Cases Rate National data Report type Reported cases Confirmed cases ASR Austria 325 3.9 158 1.9 234 2.8 350 4.1 Y C 322 3.8 3.5 Belgium 1851 - 1836 1738 1604 N 1192 Bulgaria 26 0.4 37 0.5 19 0.3 17 0.2 A 21 Croatia . 18 16 27 0.6 Cyprus 12 1.5 15 1.8 2.2 8 0.9 14 1.6 1.7 Czech Republic 300 2.9 384 3.7 335 3.2 424 4.0 337 3.1 Denmark 960 17.3 924 16.6 882 15.8 842 15.0 725 12.9 12.1 Estonia 1.1 1.4 20 24 Finland 834 15.6 779 14.5 752 13.9 724 13.3 703 12.0 France 5117 10.5 5037 10.4 4430 9.0 3687 7.6 74% 3184 6.5 6.2 Germany Greece 38 41 43 40 30 Hungary 108 107 186 202 2.0 150 Iceland 32 10.1 33 8.4 5.9 7.4 8.8 Ireland 304 6.7 357 7.8 347 342 8.3 Italy 854 713 1.2 814 977 957 Latvia 0.8 51 2.5 56 2.7 2.4 Liechtenstein Lithuania 9 7 6 Luxembourg 2 1 Malta 11 3.6 22 5.2 4.9 Netherlands 571 13.8 622 14.9 635 15.2 652 15.5 25% 550 546 13.0 12.4 Norway 748 15.4 729 14.8 626 12.6 620 12.3 569 11.1 11.3 Poland 333 351 441 540 705 Portugal Romania 80 90 79 92 62 Slovakia 57 49 84 78 Slovenia 224 10.9 255 245 11.9 278 13.5 276 13.4 12.8 Spain 2212 2220 2260 6.0 2026 5.4 80% 1856 5.0 4.7 Sweden 1456 1361 1387 14.6 1316 1159 11.0 United Kingdom 5616 4631 7.3 5208 8.2 5045 7.9 4157 6.3 EU/EEA 22071 20828 5.7 20876 20014 17533 17528 4.8 4.6 Source: Country reports. Legend: Y = yes, N = no, C = case based, · = no report, ASR: age-standardised rate Suggested citation: European Centre for Disease Prevention and Control. Annual epidemiological report 2015. Invasive pneumococcal disease. Stockholm: ECDC; 2016. © European Centre for Disease Prevention and Control, 2016. Reproduction is authorised, provided the source is acknowledged
Figure 1. Reported, confirmed cases of invasive pneumococcal disease, EU/EEA, 2014 Source: Country reports from Austria, Belgium, Bulgaria, Croatia, Cyprus, the Czech Republic, Denmark, Estonia, Finland, France, Germany, Greece, Hungary, Iceland, Ireland, Italy, Latvia, Lithuania, Luxembourg, Malta, the Netherlands, Norway, Poland, Portugal, Romania, Slovakia, Slovenia, Spain, Sweden, the United Kingdom. Suggested citation: European Centre for Disease Prevention and Control. Annual epidemiological report 2015. Invasive pneumococcal disease. Stockholm: ECDC; 2016. © European Centre for Disease Prevention and Control, 2016. Reproduction is authorised, provided the source is acknowledged
Figure 2. Number of reported, confirmed cases of invasive pneumococcal disease per 100 000 population, EU/EEA, 2014 Source: Country reports from: Austria, Bulgaria, Croatia, Cyprus, Czech Republic, Denmark, Estonia, Finland, Greece, Hungary, Iceland, Ireland, Italy, Latvia, Lithuania, Luxembourg, Malta, the Netherlands, Norway, Poland, Romania, Slovakia, Slovenia, Spain, Sweden, the United Kingdom. Suggested citation: European Centre for Disease Prevention and Control. Annual epidemiological report 2015. Invasive pneumococcal disease. Stockholm: ECDC; 2016. © European Centre for Disease Prevention and Control, 2016. Reproduction is authorised, provided the source is acknowledged
Figure 3. Cases of reported, confirmed invasive pneumococcal disease, by age and gender, EU/EEA, 2014 Source: Country reports from: Austria, Bulgaria, Cyprus, Czech Republic, Denmark, Estonia, Finland, Greece, Hungary, Iceland, Ireland, Italy, Latvia, Lithuania, Luxembourg, Malta, the Netherlands, Norway, Poland, Romania, Slovakia, Slovenia, Spain, Sweden, the United Kingdom. Suggested citation: European Centre for Disease Prevention and Control. Annual epidemiological report 2015. Invasive pneumococcal disease. Stockholm: ECDC; 2016. © European Centre for Disease Prevention and Control, 2016. Reproduction is authorised, provided the source is acknowledged
Figure 4. Seasonal distribution of reported, confirmed cases of invasive pneumococcal disease, EU/EEA, 2014 compared with 2010−2013 Source: Country reports from: Austria, Belgium, Cyprus, Denmark, Estonia, Finland, France, Greece, Hungary, Iceland, Ireland, Italy, Latvia, Lithuania, Luxembourg, Malta, the Netherlands, Norway, Poland, Romania, Slovakia, Slovenia, Spain, Sweden, the United Kingdom. Suggested citation: European Centre for Disease Prevention and Control. Annual epidemiological report 2015. Invasive pneumococcal disease. Stockholm: ECDC; 2016. © European Centre for Disease Prevention and Control, 2016. Reproduction is authorised, provided the source is acknowledged
Figure 5. Trend and number of reported, confirmed cases of invasive pneumococcal disease, EU/EEA, 2010−2014 Source: Country reports from Austria, Belgium, Cyprus, the Czech Republic, Denmark, Estonia, Finland, France, Germany, Greece, Hungary, Iceland, Ireland, Italy, Latvia, Lithuania, Malta, the Netherlands, Norway, Poland, Portugal, Romania, Slovakia, Slovenia, Spain, Sweden, the United Kingdom. Suggested citation: European Centre for Disease Prevention and Control. Annual epidemiological report 2015. Invasive pneumococcal disease. Stockholm: ECDC; 2016. © European Centre for Disease Prevention and Control, 2016. Reproduction is authorised, provided the source is acknowledged
Figure 6. Distribution of confirmed cases of invasive pneumococcal disease: most common serotypes in 2014 (n=12 980), 2013 (n=14 811) and 2012 (n=14 845) * Covered by PCV7, PCV10, PCV13 and PPV23 ~ Covered by PCV10, PCV13 and PPV23 † Covered by PCV13 and PPV23 ˄ Covered by PPV23 Source: Country reports from: Austria, Belgium, Cyprus, Czech Republic, Denmark, Estonia, Finland, France, Greece, Hungary, Iceland, Ireland, Italy, Latvia, Lithuania, Malta, Netherlands, Norway, Poland, Romania, Slovakia, Slovenia, Spain, Sweden, United Kingdom. Suggested citation: European Centre for Disease Prevention and Control. Annual epidemiological report 2015. Invasive pneumococcal disease. Stockholm: ECDC; 2016. © European Centre for Disease Prevention and Control, 2016. Reproduction is authorised, provided the source is acknowledged
Figure 7. Invasive pneumococcal disease, reported confirmed cases aged <5 years: serotype distribution by PCV vaccine type, 2011–2014 (n= 4 783) * Although serotype 6A is included in PCV13 and not in PCV7, it is considered to be a PCV7 serotype in the analysis due to documented cross-protection provided by the serotype 6B antigen in PCV7. PCV7 serotypes: 4, 6A, 6B, 9V, 14, 18C, 19F, 23F; PCV10non7 serotypes: 1, 5, 7F; PCV13non10 serotypes: 3, 19A; Non-PCV serotypes: all remaining serotypes. Suggested citation: European Centre for Disease Prevention and Control. Annual epidemiological report 2015. Invasive pneumococcal disease. Stockholm: ECDC; 2016. © European Centre for Disease Prevention and Control, 2016. Reproduction is authorised, provided the source is acknowledged
Figure 8. Susceptibility of confirmed cases of invasive pneumococcal disease to cefotaxime/ceftriaxone, penicillin and erythromycin, 2012–2014 Source: For penicillin, country reports from: Austria, Belgium, Cyprus (2012), Denmark, Estonia, Finland, France, Hungary, Iceland (2012, 2014), Ireland, Italy, Latvia (2013, 2014), Lithuania (2012, 2013), Norway, Poland, Romania (2013), Slovakia, Slovenia, Spain, United Kingdom (2012, 2013, 2014). Total number of cases – 2012: n=12 226; 2013: n=11 493; 2014: n=9 283. For erythromycin, country reports from: Austria, Cyprus (2013, 2014), Denmark, Estonia, Finland, France, Hungary, Iceland (2012, 2014), Ireland, Italy, Latvia (2013, 2014), Lithuania (2012, 2013), Norway, Poland, Romania (2013), Slovakia, Slovenia, Spain, United Kingdom (2012, 2013, 2014). Total number of cases – 2012: n=9 685; 2013: n=9 202; 2014: n=7 548. For cefotaxime/ceftriaxone, country reports from: Austria (2012, 2013), Cyprus (2012), Denmark, Estonia, Finland (2012, 2014), France (2012), Hungary, Iceland (2012, 2014), Ireland, Latvia (2013, 2014), Lithuania (2012, 2013), Norway, Poland, Romania (2013), Slovakia, Slovenia, Spain, United Kingdom (2012, 2013, 2014). Total number of cases – 2012: n=6 419; 2013: n=4 715; 2014: n=4 592. Note: SIR values (susceptible, intermediate, and resistant) are displayed as interpreted by the reporting countries. ‘Intermediate’ and ‘resistant’ were categorised as ‘non-susceptible’. Suggested citation: European Centre for Disease Prevention and Control. Annual epidemiological report 2015. Invasive pneumococcal disease. Stockholm: ECDC; 2016. © European Centre for Disease Prevention and Control, 2016. Reproduction is authorised, provided the source is acknowledged
Table. Invasive pneumococcal disease, surveillance systems overview, 2014 Surveillance Data reported by Case definition used characteristics Country Data source L P H O Austria AT-Epidemiegesetz Cp Co C Y EU-2008 Belgium BE-REFLAB V Se A N Bulgaria BG-NATIONAL_SURVEILLANCE Croatia HR-CNIPH EU-2012 Cyprus CY-NOTIFIED_DISEASES Czech Republic CZ-NRL-STR Denmark DK-LAB Not specified/unknown Estonia EE-NAKIS Finland FI-NIDR France FR-EPIBAC Greece EL-Notification/Laboratory data Hungary HU-NRL_PNEU Iceland IS-SUBJECT_TO_REGISTRATION Ireland IE-PNEU Italy IT-MENINGITIS Latvia LV-BSN Lithuania LT-COMMUNICABLE_DISEASES Luxembourg LU-SYSTEM1 EU-2002 Malta MT-DISEASE_SURVEILLANCE Netherlands NL-NRBM Norway NO-MSIS_A Poland PL-NATIONAL_SURVEILLANCE Romania RO-RNSSy Slovakia SK-EPIS Slovenia SI-SURVIVAL Spain ES-NRL Sweden SE-SMINET United Kingdom UK-PNEUMOCOCCAL Surveillance characteristics: compulsory (Cp), comprehensive (co), voluntary (V), other (O), active (A), passive (P), case-based (C), aggregated (A) Data reported by: laboratories (L), physicians (P), hospitals (H), other (O) Suggested citation: European Centre for Disease Prevention and Control. Annual epidemiological report 2016. Invasive pneumococcal disease. Stockholm: ECDC; 2016. © European Centre for Disease Prevention and Control, 2016. Reproduction is authorised, provided the source is acknowledged