Volume 385, Issue 9972, Pages (March 2015)

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Volume 385, Issue 9972, Pages 947-955 (March 2015) Mechanical versus manual chest compression for out-of-hospital cardiac arrest (PARAMEDIC): a pragmatic, cluster randomised controlled trial Prof Gavin D Perkins, MD, Ranjit Lall, PhD, Prof Tom Quinn, M Phil, Prof Charles D Deakin, MD, Prof Matthew W Cooke, PhD, Jessica Horton, MSc, Prof Sarah E Lamb, DPhil, Anne-Marie Slowther, DPhil, Prof Malcolm Woollard, MPH, Andy Carson, FRCGP, Mike Smyth, MSc, Richard Whitfield, BSc, Amanda Williams, MA, Helen Pocock, MSc, John J M Black, FCEM, John Wright, FCEM, Kyee Han, FCEM, Prof Simon Gates, PhD The Lancet Volume 385, Issue 9972, Pages 947-955 (March 2015) DOI: 10.1016/S0140-6736(14)61886-9 Copyright © 2015 Perkins et al. Open Access article distributed under the terms of CC BY Terms and Conditions

Figure 1 Trial profile *Seven met more than one exclusion criteria. †Reasons LUCAS-2 not used: 78 because of crew not trained; 168 because of crew error; 26 no device in vehicle; 102 unsuitable patients (58 patient too large, 22 patient too small, 22 other reason–eg, chest deformity), 14 device issues, 140 not possible to use device; 110 reason unknown. Reasons for LUCAS-2 use in control group were crew error. The Lancet 2015 385, 947-955DOI: (10.1016/S0140-6736(14)61886-9) Copyright © 2015 Perkins et al. Open Access article distributed under the terms of CC BY Terms and Conditions

Figure 2 Meta-analysis of the outcomes survived event and survival to hospital discharge or 30 days (A) Survival to discharge or 30 days. (B) Survived event. (C) Survival with CPC 1–2. The Lancet 2015 385, 947-955DOI: (10.1016/S0140-6736(14)61886-9) Copyright © 2015 Perkins et al. Open Access article distributed under the terms of CC BY Terms and Conditions