Figure 4 Tissue infiltration and lymphadenopathy in patients with CTLA4 mutations Figure 4 | Tissue infiltration and lymphadenopathy in patients with CTLA4.

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Figure 4 Tissue infiltration and lymphadenopathy in patients with CTLA4 mutations Figure 4 | Tissue infiltration and lymphadenopathy in patients with CTLA4 mutations. a,b | Duodenal tissue stained for CD4. c | High-resolution chest CT scan of the lungs (arrows indicate granulomatous-lymphocytic infiltrations). d | Pulmonary tissue showing lymphoid fibrotic lesions stained for CD4. e | MRI scan of lymphocytic proliferation in the pelvic area (arrows indicate enlarged lymph nodes). f | CD4 staining of bone marrow tissue. g | Gadolinium-enhanced MRI scan of the cerebellum (arrows indicate lesions). h | Tissue from a resected cerebellar lesion stained for CD3. Reproduced from Schubert, D. et al. Autosomal dominant immune dysregulation syndrome in humans with CTLA4 mutations. Nat. Med. 20, 1410–6 (2014). Reproduced from Schubert, D. et al. Autosomal dominant immune dysregulation syndrome in humans with CTLA4 mutations. Nat. Med. 20, 1410–6 (2014). Schmidt, R. E. et al. (2017) Autoimmunity and primary immunodeficiency: two sides of the same coin? Nat. Rev. Rheumatol. doi:10.1038/nrrheum.2017.198