CPR 1.1. Identifying Patients and Initiating Evaluation   American Journal of Kidney Diseases  Volume 47, Pages S17-S27 (May 2006) DOI: 10.1053/j.ajkd.2006.03.012 Copyright © 2006 National Kidney Foundation, Inc. Terms and Conditions

Fig 3 Relationship between Hb level and eGFR. Data represent a cross-sectional survey of individuals randomly selected from the general US population (NHANES III). Median and 95% confidence limits around the 95th and 5th percentiles are shown for males and females at each eGFR interval. Adapted with permission.27 American Journal of Kidney Diseases 2006 47, S17-S27DOI: (10.1053/j.ajkd.2006.03.012) Copyright © 2006 National Kidney Foundation, Inc. Terms and Conditions

Fig 4 Relationship between eGFR and prevalence of anemia as defined by differing Hb levels for (A) males and (B) females. Data from NHANES III. Reprinted with permission.27 American Journal of Kidney Diseases 2006 47, S17-S27DOI: (10.1053/j.ajkd.2006.03.012) Copyright © 2006 National Kidney Foundation, Inc. Terms and Conditions

Fig 5 Prevalence of anemia by CKD stage. Anemia, defined as an Hb level less than 13.0 g/dL in males and less than 12.0 g/dL in females, was plotted by stage of CKD in results from NHANES III compared with NHANES IV. USRDS 2004.28 American Journal of Kidney Diseases 2006 47, S17-S27DOI: (10.1053/j.ajkd.2006.03.012) Copyright © 2006 National Kidney Foundation, Inc. Terms and Conditions

Fig 6 Relationship between level of renal function, reflected by SCr level or GFR, and prevalence of anemia, defined at different Hb cutoff levels, among patients under the care of physicians. Reprinted with permission.29 American Journal of Kidney Diseases 2006 47, S17-S27DOI: (10.1053/j.ajkd.2006.03.012) Copyright © 2006 National Kidney Foundation, Inc. Terms and Conditions

Fig 7 Hb percentiles by GFR in the Canadian Multicentre Longitudinal Cohort Study. Patients were referred to nephrologists between 1994 and 1997. Results shown exclude patients receiving ESA therapy or with an arteriovenous fistula. Reprinted with permission.4,30 American Journal of Kidney Diseases 2006 47, S17-S27DOI: (10.1053/j.ajkd.2006.03.012) Copyright © 2006 National Kidney Foundation, Inc. Terms and Conditions

Fig 8 Prevalence of low Hb level by category of GFR in the Canadian Multicentre Longitudinal Cohort Study. Reprinted with permission.4,30 American Journal of Kidney Diseases 2006 47, S17-S27DOI: (10.1053/j.ajkd.2006.03.012) Copyright © 2006 National Kidney Foundation, Inc. Terms and Conditions

Fig 9 Prevalence of low Hb level by eGFR in patients with diabetes compared with the general population. Open circles (○) indicate the diabetic population, while closed circles (●) represent general population data from NHANES III. A: Hb ≤11 g/dL; B: WHO criteria (men, Hb <13 g/dL; women, Hb <12 g/dL). Reprinted with permission.35 American Journal of Kidney Diseases 2006 47, S17-S27DOI: (10.1053/j.ajkd.2006.03.012) Copyright © 2006 National Kidney Foundation, Inc. Terms and Conditions

Fig 10 Changes in Hb levels and eGFR over 2 years in adult patients with CKD stages 3 and 4 not treated with ESA. Oral iron supplements and occasional IV iron treatment were administered to maintain TSAT at greater than 20% and ferritin levels greater than 100 ng/mL. Data given as mean ± SD. Although mean Hb levels showed little or no change, the number of study patients remaining without ESA therapy declined. Results courtesy of the authors, from control group patients previously described. Reprinted with permission.39 American Journal of Kidney Diseases 2006 47, S17-S27DOI: (10.1053/j.ajkd.2006.03.012) Copyright © 2006 National Kidney Foundation, Inc. Terms and Conditions

Fig 11 Distribution of Hb levels in adult males and females by age group. The 5th, 50th, and 95th percentiles are shown for each age group. In females, results reflect only individuals with serum ferritin greater than 25 ng/mL or TSAT greater than 16% because lower values may contribute to low Hb levels. Dash-dot-dash lines indicate recommended cutoff value to define anemia. (Source: US Renal Data System [USRDS] special data request, NHANES 1999-2002 data set). American Journal of Kidney Diseases 2006 47, S17-S27DOI: (10.1053/j.ajkd.2006.03.012) Copyright © 2006 National Kidney Foundation, Inc. Terms and Conditions