Volume 14, Issue 2, Pages (August 2011)

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Volume 14, Issue 2, Pages 149-150 (August 2011) MiRs with a Sweet Tooth Anders M. Näär Cell Metabolism Volume 14, Issue 2, Pages 149-150 (August 2011) DOI: 10.1016/j.cmet.2011.07.005 Copyright © 2011 Elsevier Inc. Terms and Conditions

Figure 1 Model of miR-103/107 Regulation of Insulin Sensitivity and Glucose Homeostasis (A) miR-103/107 were found to be elevated in liver of obese mice. Data suggest that increased expression of miR-103/107 in liver and adipose tissues could contribute to insulin resistance and glucose intolerance. (B) Caveolin-1 (Cav1) was shown to be a direct target of miR-103/107 in adipocytes, and downregulation of Cav1 expression by miR-103/107 resulted in decreased insulin (Ins) signaling through the insulin receptor (InsR) to AKT and decreased glucose uptake. Cell Metabolism 2011 14, 149-150DOI: (10.1016/j.cmet.2011.07.005) Copyright © 2011 Elsevier Inc. Terms and Conditions