Effects of Mineralocorticoid Receptor Antagonists on the Risk of Sudden Cardiac Death in Patients With Left Ventricular Systolic DysfunctionClinical Perspective.

Slides:

Advertisements

Similar presentations

© 2010, American Heart Association. All rights reserved. Hospital Performance Recognition with the Get with the Guidelines Program and Mortality for Acute.

Advertisements

Canadian Diabetes Association Clinical Practice Guidelines Treatment of Diabetes in People with Heart Failure Chapter 28 Jonathan G. Howlett, John C. MacFadyen.

Appendix: Clinical Guidelines VBWG. I Intervention is useful and effective III Intervention is not useful or effective and may be harmful A Data derived.

RALES: Randomized Aldactone Evaluation Study Purpose To determine whether the aldosterone antagonist spironolactone reduces mortality in patients with.

Treatment and Risk in Heart Failure: Gaps in Evidence or Quality? Pamela N. Peterson, MD MSPH; John S. Rumsfeld, MD PhD; Li Liang PhD; Adrian F. Hernandez,

Risk profile and benefits from Gp IIb-IIIa inhibitors among patients with ST-segment elevation myocardial infarction treated with primary angioplasty:

Flow diagram of the systematic literature search indicating the inclusion and exclusion process of studies Liakopoulos OJ, et al. Eur Heart J 2008;29:

Rosuvastatin 10 mg n=2514 Placebo n= to 4 weeks Randomization 6weeks3 monthly Closing date 20 May 2007 Eligibility Optimal HF treatment instituted.

Date of download: 5/28/2016 Copyright © The American College of Cardiology. All rights reserved. From: Omega-3 Polyunsaturated Fatty Acids and Cardiovascular.

Date of download: 5/30/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Aspirin for the Prevention of Cardiovascular Events.

Date of download: 6/3/2016 Copyright © The American College of Cardiology. All rights reserved. From: Incidence, Temporal Trends, and Prognostic Impact.

Date of download: 6/3/2016 Copyright © The American College of Cardiology. All rights reserved. From: Relationship Between Operator Volume and Adverse.

Date of download: 6/24/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Long-term Prognosis of Acute Kidney Injury After.

Date of download: 7/5/2016 Copyright © The American College of Cardiology. All rights reserved. From: Early Aldosterone Blockade in Acute Myocardial Infarction:

Trends in Hospitalizations and Outcomes for Acute Cardiovascular Disease and Stroke, 1999–2011CLINICAL PERSPECTIVE by Harlan M. Krumholz, Sharon-Lise T.

Date of download: 7/9/2016 Copyright © The American College of Cardiology. All rights reserved. From: Making Sense of Statistics in Clinical Trial Reports:

Admission Glucose and Mortality in Elderly Patients Hospitalized With Acute Myocardial Infarction by Mikhail Kosiborod, Saif S. Rathore, Silvio E. Inzucchi,

Date of download: 9/19/2016 Copyright © The American College of Cardiology. All rights reserved. From: What resting heart rate should one aim for when.

Implantable Cardioverter-Defibrillators for Primary Prevention of Sudden Cardiac Death in CKD: A Meta-analysis of Patient-Level Data From 3 Randomized.

John W. Pickering, PhD, Matthew T. James, MD, PhD, FRCPC, Suetonia C

Flow of Individuals Through the Vitamin E and Vitamin C Components of the Physicians’ Health Study II Howard D. Sesso et al. JAMA 2008;300:

Congestive heart failure: Treat the disease, not the symptom—Return to normalcy Gerald D. Buckberg, MD The Journal of Thoracic and Cardiovascular Surgery

Circ Arrhythm Electrophysiol

Copyright © 2002 American Medical Association. All rights reserved.

Copyright © 2006 American Medical Association. All rights reserved.

Echocardiographic modalities for evaluation and risk stratification of heart failure patients. 3D indicates 3-dimensional; EF, ejection fraction; LA, left.

Copyright © 2009 American Medical Association. All rights reserved.

Circ Cardiovasc Interv

Forecasting the Impact of Heart Failure in the United States

Cardiac Resynchronization Therapy Using Quadripolar Versus Non‐Quadripolar Left Ventricular Leads Programmed to Biventricular Pacing With Single‐Site Left.

Circ Cardiovasc Interv

Atrial Fibrillation and Mortality in Heart FailureClinical Perspective

by Alexander Kulik, Ian G. Burwash, Varun Kapila, Thierry G

Plasma Vitamin C, but Not Vitamin E, Is Associated With Reduced Risk of Heart Failure in Older MenClinical Perspective by Sasiwarang Goya Wannamethee,

Valsartan in Acute Myocardial Infarction Trial Investigators

Modest Increase in Peak VO2 Is Related to Better Clinical Outcomes in Chronic Heart Failure PatientsClinical Perspective by Ann M. Swank, John Horton,

Circ Cardiovasc Qual Outcomes

Circ Cardiovasc Interv

Prognostic Value of Changes in Galectin-3 Levels Over Time in Patients With Heart FailureClinical Perspective by A. Rogier van der Velde, Lars Gullestad,

Risk of Heart Failure Among Postmenopausal WomenCLINICAL PERSPECTIVE

by Clarisse Toledo, George Thomas, Jesse D

Optimal Pacing for Right Ventricular and Biventricular Devices

by Peter J. Schwartz, Maria Teresa La Rovere, Gaetano M

Circ Cardiovasc Interv

Circ Cardiovasc Interv

Ahmed Abuzaid, MD, Carly Fabrizio, DO, Kevin Felpel, MD, Haitham S

Prevalence, Predictors, and Outcomes in Treatment-resistant Hypertension in Patients with Coronary Disease Sripal Bangalore, MD, MHA, Rana Fayyad, PhD,

Ragavendra R. Baliga, MD, MBA Heart Failure Clinics

Effect of beta-blockers on perioperative outcomes in vascular and endovascular surgery: a systematic review and meta-analysis S Hajibandeh, S Hajibandeh,

Baseline characteristics of patients

Aditya J. Ullal, BA, Ramy S. Abdelfattah, MD, Euan A

National Quality Assessment Evaluating Spironolactone Use During Hospitalization for Acute Myocardial Infarction (AMI) in China: China Patient-centered.

Use of Targeted Temperature Management After Out-of-hospital Cardiac Arrest: A Meta- Analysis of Randomized Controlled Trials Ahmed Mahmoud, MD, Islam.

Database-specific risk of ventricular arrhythmia associated with current use of azithromycin compared with current use of amoxicillin (2-stage random-effects.

John A. Bittl et al. JACC 2016;68:

The Safety and Efficacy of Mineralocorticoid Receptor Antagonists in Patients Who Require Dialysis: A Systematic Review and Meta-analysis Kevin Quach,

Congestive heart failure: Treat the disease, not the symptom—Return to normalcy Gerald D. Buckberg, MD The Journal of Thoracic and Cardiovascular Surgery

Impact of physiologic pacing versus right ventricular pacing among patients with left ventricular ejection fraction greater than 35%: A systematic review.

Questions and answers about the STICH trial: A different perspective

A decade after the Surgical Treatment for Ischemic Heart Failure (STICH) trial: Weaving firm clinical recommendations from lessons learned Robert E.

Berger JS, et al. JAMA 2009;301:

Flow diagram for exclusions of trials identified RCT indicates randomized controlled trial Hulten E, et al. Arch Intern Med 2006;166:

Eplerenone Is Not Superior to Older and Less Expensive Aldosterone Antagonists Saurav Chatterjee, MD, Chaim Moeller, MD, Nidhi Shah, MD, Oluwaseyi Bolorunduro,

Ahmed Abuzaid, MD, Carly Fabrizio, DO, Kevin Felpel, MD, Haitham S

Volume 80, Issue 6, Pages (September 2011)

An ACCORD BP sub-analysis HR: 1.06; 95%CI: ; P=0.61

EMPA-REG OUTCOME: Cumulative incidence of the primary outcome

An ACCORD BP sub-analysis HR: 1.06; 95%CI: ; P=0.61

Prosthesis–patient mismatch after aortic valve replacement predominantly affects patients with preexisting left ventricular dysfunction: Effect on survival,

Increase of physical activity over time associated with lower HF risk

Presentation transcript:

Effects of Mineralocorticoid Receptor Antagonists on the Risk of Sudden Cardiac Death in Patients With Left Ventricular Systolic DysfunctionClinical Perspective by Srinivas R. Bapoje, Amit Bahia, John E. Hokanson, Pamela N. Peterson, Paul A. Heidenreich, JoAnn Lindenfeld, Larry A. Allen, and Frederick A. Masoudi Circ Heart Fail Volume 6(2):166-173 March 19, 2013 Copyright © American Heart Association, Inc. All rights reserved.

Flow diagram of study selection. Flow diagram of study selection. SCD indicates sudden cardiac death. Srinivas R. Bapoje et al. Circ Heart Fail. 2013;6:166-173 Copyright © American Heart Association, Inc. All rights reserved.

Forest Plot comparing sudden cardiac death (SCD), cardiovascular, and total mortality in patients treated with and without mineralocorticoid receptor antagonists (MRAs). Forest Plot comparing sudden cardiac death (SCD), cardiovascular, and total mortality in patients treated with and without mineralocorticoid receptor antagonists (MRAs). AREA-IN-CHF indicates Antiremodeling Effect of Canrenone in Patients with Mild Chronic Heart failure; CI, confidence interval; EMPHASIS-HF, Eplerenone in Mild Patients Hospitalization and Survival Study in Heart Failure; EPHESUS, Eplerenone Postacute Myocardial Infarction Heart Failure Efficacy and Survival Study; OR, odds ratio; and RALES, Randomized Aldactone Evaluation Study. Srinivas R. Bapoje et al. Circ Heart Fail. 2013;6:166-173 Copyright © American Heart Association, Inc. All rights reserved.