Targeting the PARP DNA repair pathway enhanced cytotoxicity induced by chemotherapy. Targeting the PARP DNA repair pathway enhanced cytotoxicity induced.

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Targeting the PARP DNA repair pathway enhanced cytotoxicity induced by chemotherapy. Targeting the PARP DNA repair pathway enhanced cytotoxicity induced by chemotherapy. A, Dose-response curves for IDH1 mutant cells treated with TMZ and Ola (n = 3). B, Annexin-V apoptosis analysis demonstrated the potentiation effect of Ola for TMZ chemotherapy. C, Quantification of apoptotic cells in IDH1 mutant cells treated with TMZ and/or Ola. Yanxin Lu et al. Cancer Res 2017;77:1709-1718 ©2017 by American Association for Cancer Research