A B SK-N-SH cells, 24 h after irradiation SK-N-SH cells, 48 h

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A B SK-N-SH cells, 24 h after irradiation SK-N-SH cells, 48 h 0 Gy 5 Gy Apo G1 G2/M Apo G1 G2/M Apo G1 G2/M Apo G1 G2/M Cont 3 61 20% 4 70 23% 0 Gy 2 71 17% 2 76 9% BMS 62 34 2% 81 18 1% 5 Gy 17 54 19% 38 38 10% Stat3 -inh6 26 68 5% 55 51 3% 10 Gy 40 36 13% 59 34 3% Cell number DNA content LY 28 70% 76 23% Cell number DNA content Suppl. Fig. 3. (A, B). Radiation response of SK-N-SH neuroblastoma cells in the absence and in the presence of inhibitors of the cell survival pathway BMS345541 (IKK-NF-kB), Stat3-inhibitor-6 and LY294002 (PI3K-AKT). Cell cycle-apoptosis analysis was performed using PI staining of DNA and FACS analysis.