1. Effects of NGF

2. Developmental processes during which apoptosis can occur

3. Glial survival depends on growth factor from axon

4. Apoptosis vs. Necrosis

5. Apoptotic cell

6. DNA Fragmentation

7. Sources of trophic signals

8. Effects of targets and afferents

9. Signal-activation of caspase

10. Bax Activation PI3 Kinase NOT activated Akt NOT activated Cytosolic BAX migrates to mito. Cytochrome C release Caspase 9 Caspase 3

11. BDNF Trk B Y-P SHC RAS PI3 kinase Akt Blocks BAX migration To the mitochondria. No Cytochrome C release No Caspase activation Bax Inhibition