HIV/HCV Co-Infection Case

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Presentation transcript:

HIV/HCV Co-Infection Case

Disclosures

Treatment History

Laboratory Values

SVR in HIV/HCV Pts According to IL28B

Factors Associated with SVR in HIV HCV Treated Pts.

IL-28B and DAA

Laboratory Values

Any other issues that need to be addressed before treatment?

Insulin Resistance Influences Response to Treatment with PegIFN/RBV in HIV/HCV Co-Infected Patients

Insulin Resistance Influences Response to Re-Treatment with PegIFN/RBV in HIV/HCV Co-Infected Patients

Multi-variable Analysis Outcome = SVR

Does Vitamin D Play a Role?

Does Vitamin D Play a Role?

June 2011

What do you recommend to this HIV-HCV cirrhotic patient?

Is the patient’s HIV regimen compatible with DAA?

DAA and co-infected patients

Telaprevir and co-infected: Study 110

Telaprevir and co-infected: Study 110

Boceprevir and co-infected

Boceprevir and co-infected

Pharmacokinetic interactions

Summer 2011

HCV viral load

CBC

Cytopenias and DAA

What would you recommend?

Growth factors and hepatitis C treatment

Growth factors and hepatitis C treatment

EPO

G-CSF

Thrombopoietic agents

CBC

January 2012

RGT

Telaprevir response guided therapy (RGT)

February 13th 2012

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