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World Epidemiology. Are HIV and Other Chronic Diseases Models Applicable to Viral Hepatitis? Focus on HCV.

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Presentation on theme: "World Epidemiology. Are HIV and Other Chronic Diseases Models Applicable to Viral Hepatitis? Focus on HCV."— Presentation transcript:

1 Are HIV and Other Chronic Diseases Models Applicable to Viral Hepatitis? Focus on HCV

2 World Epidemiology

3 HCV Epidemiology

4

5 HCV Subtype Distribution: A Mosaic of Overlapping Sub-Epidemics

6 HIV-1 Subtypes Worldwide

7 U.S. Epidemiology

8 HCV and HIV in the US

9 HIV/HCV in the U.S.: Epidemiological Overlap

10 Prevalence of HCV Ab by Demographic Characteristics 1999-2002 NHANES

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12

13 Relative Importance of Risk Factors for Remote and Recent HCV Infection

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15 Testing and Care

16 Current Recs for HCV Testing

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19 U.S.: New HIV Infections / Year

20 HCV infection in the U.S.

21 CDC Medical Monitoring Project: HIV Update

22 Virology

23 Viral Genetic Diversity

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25 Life Cycle of HIV

26 HCV and HIV Polymerases: Similar Structure and Function

27 HCV and HIV Proteases

28 Virology: Summary

29 Natural History

30 HIV and HCV: Much in Common

31 HCV: Natural History

32 Natural History of HIV Infection

33 Age-Adjusted HCV Mortality: 1995-2005

34

35 Treatment

36 Assessing Virologic Response in HCV Therapy

37 HIV Therapy:

38

39 HCV Protease Inhibitors

40 Independent Predictors of Sustained Virologic Response (Logistic Regression)

41 HIV Drug Approval:

42 ART:

43 HIV Drug Approval:

44 HIV Drug-Resistance Testing

45 HIV Cure (N=1)

46 HCV and HIV: Treatment Issues

47 HCV + HIV: Healthcare Team

48 HCV and HIV: Summary

49 Acknowledgments


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