Effect of Maternal Influenza Vaccination on Respiratory Disease among Infants Based on Protocol: Effect of Maternal Influenza Vaccination on Respiratory.

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Presentation transcript:

Effect of Maternal Influenza Vaccination on Respiratory Disease among Infants Based on Protocol: Effect of Maternal Influenza Vaccination on Respiratory Disease among Infants [NNR ]

Background

What is influenza ? Influenza is a germ that can make people of any age sick. Commonly known as the flu Is a winter time illness Can cause fever, muscle aches, cough, and runny nose, and serious symptoms that require hospitalization

Babies Everywhere Less than 6 Months Old are at High Risk for Influenza Hospitalization Izurietta 2000; Neuzil 2000

How do we prevent it? ** Vaccination is the best way to prevent influenza!!

Problem: There is no vaccine for babies less than 6 months of age …

Possible Solution? …We wanted to see if giving the flu vaccine to pregnant women can protect their babies from the flu

Study Conduct

How was the maternal flu study conducted? Study conducted during the flu season (cold months of the year) between Enrolled mother-infant pairs immediately after birth and followed infants for 6 months or to the end of flu season. Tested whether giving the flu vaccine to pregnant women can prevent their babies from getting the flu.

Before Starting the Study We Needed to Get Approval… We got approval from Navajo and White Mountain Apache Tribes. We also asked mothers for permission to enroll them and their infants in the study.

Who participated in the Study? 1162 infant and mother pairs. Service Units participating in the study were: Fort Defiance, Gallup, Chinle, Shiprock, Tuba City, Winslow and Whiteriver.

How was the maternal flu study conducted? Blood was collected to test for antibodies (germ fighters) to the influenza virus.

How was the maternal flu study conducted? Babies followed throughout the study to see if they went to the doctors for flu-like illness.

How was the maternal flu study conducted? If a baby went to the doctors for flu-like illness, secretions from the babys nose were collected to test for influenza virus.

How was the maternal flu study conducted? All information collected was entered into computer for analysis.

Study Results

1160 mother-infant pairs 573 given the flu shot 31 Lab-confirmed flu cases 293 Flu-like Symptoms 76 Hospitalized for flu like symptoms 587 not given the flu shot 52 Lab-confirmed flu cases 312 Flu-like Symptoms 117 Hospitalized for flu like symptoms Maternal influenza vaccination helps protect baby against influenza

Conclusions Influenza vaccination during pregnancy … 1.) Helps prevent babies less than 6 months from getting the flu 2.) Reduces chance of hospitalizations for babies with flu-like symptoms

Acknowledgements Participants from the Navajo and White Mountain Apache tribes Community members who supported the project Nurses and research program assistants IRBs of the Navajo Nation, Phoenix Area IHS, and Johns Hopkins School of Public Health The Centers for Disease Control Indian Health Service for their collaboration and support

Thank You!!