Volume 153, Issue 3, Pages e1 (September 2017)

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Volume 153, Issue 3, Pages 689-701.e1 (September 2017) Tests for Serum Transglutaminase and Endomysial Antibodies Do Not Detect Most Patients With Celiac Disease and Persistent Villous Atrophy on Gluten-free Diets: a Meta-analysis Jocelyn A. Silvester, Satya Kurada, Andrea Szwajcer, Ciarán P. Kelly, Daniel A. Leffler, Donald R. Duerksen Gastroenterology Volume 153, Issue 3, Pages 689-701.e1 (September 2017) DOI: 10.1053/j.gastro.2017.05.015 Copyright © 2017 AGA Institute Terms and Conditions

Figure 1 Performance of tTG IgA for detection of persistent villous atrophy in patients with biopsy-confirmed celiac disease on a GFD. (A) Forest plot of sensitivity and specificity of tTG IgA for persistent villous atrophy on a GFD. (B) Summary ROC curve of tTG IgA for persistent villous atrophy. In addition to individual and summary points, the 95% confidence region (solid circle) denotes the precision of the pooled estimate of the available studies and the 95% prediction region (dashed circle) shows the area where the next study is likely to lie, which reflects variability among studies. Gastroenterology 2017 153, 689-701.e1DOI: (10.1053/j.gastro.2017.05.015) Copyright © 2017 AGA Institute Terms and Conditions

Figure 2 Performance of EMA IgA for detection of persistent villous atrophy in patients with biopsy-confirmed celiac disease on a GFD. (A) Forest plot of sensitivity and specificity of EMA IgA for persistent villous atrophy on a GFD. (B) Summary ROC curve of EMA IgA for persistent villous atrophy. In addition to individual and summary points, the 95% confidence region (solid circle) denotes the precision of the pooled estimate of the available studies and the 95% prediction region (dashed circle) shows the area where the next study is likely to lie, which reflects variability among studies. 1Monkey, 2human. Gastroenterology 2017 153, 689-701.e1DOI: (10.1053/j.gastro.2017.05.015) Copyright © 2017 AGA Institute Terms and Conditions