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Treatment of Clostridium difficile-Associated Disease

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Presentation on theme: "Treatment of Clostridium difficile-Associated Disease"— Presentation transcript:

1 Treatment of Clostridium difficile-Associated Disease
Daniel A. Leffler, J. Thomas Lamont  Gastroenterology  Volume 136, Issue 6, Pages (May 2009) DOI: /j.gastro Copyright © 2009 AGA Institute Terms and Conditions

2 Figure 1 Pathogenesis of C difficile infection.
Gastroenterology  , DOI: ( /j.gastro ) Copyright © 2009 AGA Institute Terms and Conditions

3 Figure 2 Age-related prevalence of antibody to C difficile toxin A and B. Modified from Viscidi et al.6 Gastroenterology  , DOI: ( /j.gastro ) Copyright © 2009 AGA Institute Terms and Conditions

4 Figure 3 Recent increase in reported treatment failures for metronidazole. Modified from Aslam et al.46 Gastroenterology  , DOI: ( /j.gastro ) Copyright © 2009 AGA Institute Terms and Conditions

5 Figure 4 Equivalent response of low and high dose vancomycin. (Modified with permission from Fekety et al.42) Gastroenterology  , DOI: ( /j.gastro ) Copyright © 2009 AGA Institute Terms and Conditions

6 Figure 5 Vancomycin is more effective than metronidazole for severe C difficile infection. Modified with permission from Zar et al.48 Gastroenterology  , DOI: ( /j.gastro ) Copyright © 2009 AGA Institute Terms and Conditions

7 Daniel A. Leffler Gastroenterology  , DOI: ( /j.gastro ) Copyright © 2009 AGA Institute Terms and Conditions

8 J. Thomas Lamont Gastroenterology  , DOI: ( /j.gastro ) Copyright © 2009 AGA Institute Terms and Conditions


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