Association Analyses Identify Three Susceptibility Loci for Vitiligo in the Chinese Han Population Xian-Fa Tang, Zheng Zhang, Da-Yan Hu, Ai-E Xu, Hai-Sheng.

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Association Analyses Identify Three Susceptibility Loci for Vitiligo in the Chinese Han Population Xian-Fa Tang, Zheng Zhang, Da-Yan Hu, Ai-E Xu, Hai-Sheng Zhou, Liang-Dan Sun, Min Gao, Tian-Wen Gao, Xing-Hua Gao, Hong-Duo Chen, Hong-Fu Xie, Cai-Xia Tu, Fei Hao, Ri-Na Wu, Fu-Ren Zhang, Ling Liang, Xiong-Ming Pu, Jian-Zhong Zhang, Jian-Wen Han, Gong-Pu Pan, Jia-Qiang Wu, Kai Li, Ming-Wan Su, Wei-Dong Du, Wei-Jia Zhang, Jian-Jun Liu, Lei-Hong Xiang, Sen Yang, You-Wen Zhou, Xue-Jun Zhang Journal of Investigative Dermatology Volume 133, Issue 2, Pages 403-410 (February 2013) DOI: 10.1038/jid.2012.320 Copyright © 2013 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 1 Genome-wide association results from the initial genome-wide association study (GWAS) analysis. (a) The genome-wide P-values of the Cochran–Armitage trend test from 493,909 polymorphic single-nucleotide polymorphisms (SNPs) in 1,117 vitiligo cases and 1,701 controls of the Chinese Han ancestry are presented. The chromosomal distribution of all the P-values (-log10P-values) is shown. (b) Quantile–quantile (Q–Q) plots of the observed P-values for association. The gray line is for null expectation. The plot in purple is for P-values for SNPs excluding the 4,031 SNPs within the major histocompatibility complex (MHC) region (6p21: 25–34Mb). Journal of Investigative Dermatology 2013 133, 403-410DOI: (10.1038/jid.2012.320) Copyright © 2013 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 2 Association scatter plots for three susceptibility loci. According to the genome-wide single-marker association analysis using the Cochran–Armitage trend test, the P-values of single-nucleotide polymorphisms (SNPs) (shown as -log10 values in y-axis) were plotted against their map positions (x-axis). The color of each SNP spot reflects its r2 with the top SNP (large red diamond) within each association locus, changing from red to white. Estimated recombination rates (based on the combined CHB and JPT samples from the HapMap project) were plotted in light blue. Gene annotations were adapted from the University of California Santa Cruz Genome Browser (http://genome.ucsc.edu/). (a) 12q13.2, (b) 11q23.3, and (c) 10q22.1. Journal of Investigative Dermatology 2013 133, 403-410DOI: (10.1038/jid.2012.320) Copyright © 2013 The Society for Investigative Dermatology, Inc Terms and Conditions