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Volume 79, Issue 1, Pages (January 2013)

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1 Volume 79, Issue 1, Pages 33-39 (January 2013)
Clinical modes of EGFR tyrosine kinase inhibitor failure and subsequent management in advanced non-small cell lung cancer  Jin-Ji Yang, Hua-Jun Chen, Hong-Hong Yan, Xu-Chao Zhang, Qing Zhou, Jian Su, Zhen Wang, Chong-Rui Xu, Yi-Sheng Huang, Bin- Chao Wang, Xue-Ning Yang, Wen-Zhao Zhong, Qiang Nie, Ri-Qiang Liao, Ben-Yuan Jiang, Song Dong, Yi-Long Wu  Lung Cancer  Volume 79, Issue 1, Pages (January 2013) DOI: /j.lungcan Copyright © 2012 Elsevier Ireland Ltd Terms and Conditions

2 Fig. 1 Grouping model according to clinical factors. (A) One-hundred and twenty trial patients. (B) One-hundred and seven routine patients. The X axis (duration of disease control). The Y axis (volume doubling time, VDT) represents the growth rate of target lesions between the two latest consecutive assessments, and was calculated according to previous reports [21,30,31]. The Z axis (progressive involvement) refers to the extent of non-target lesion involvement. Lung Cancer  , 33-39DOI: ( /j.lungcan ) Copyright © 2012 Elsevier Ireland Ltd Terms and Conditions

3 Fig. 2 Kaplan–Meier curves of patients in different groups. (A) Progression-free survival. (B) Post-progression survival. (C) Overall survival in patients of different groups. (D) Overall survival in the gradual progression group with different subsequent treatments. Lung Cancer  , 33-39DOI: ( /j.lungcan ) Copyright © 2012 Elsevier Ireland Ltd Terms and Conditions

4 Fig. 3 Clinical management of different EGFR-TKI failure modes. EGFR, epidermal growth factor receptor; TKIs, tyrosine kinase inhibitors; NSCLC, non-small cell lung cancer. Lung Cancer  , 33-39DOI: ( /j.lungcan ) Copyright © 2012 Elsevier Ireland Ltd Terms and Conditions

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