Nm23-H1 Regulates Glucose-Stimulated Insulin Secretion in Pancreatic β-Cells via Arf6-Rac1 Signaling Axis Cell Physiol Biochem 2013;32:533-541 - DOI:10.1159/000354457.

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Nm23-H1 Regulates Glucose-Stimulated Insulin Secretion in Pancreatic β-Cells via Arf6-Rac1 Signaling Axis Cell Physiol Biochem 2013;32:533-541 - DOI:10.1159/000354457 Fig. 1. siRNA-mediated knockdown of nm23-H1 inhibits glucose-stimulated insulin secretion in INS-1 832/13 cells. GSIS was quantitated in INS-1 832/13 cells transfected with either scrambled or nm23-siRNA. A Western blot indicating the knockdown of nm23-H1 was provided in the inset. Data are mean ± SEM from 3 determinations in each case. * p<0.05 vs LG [5mM], and ** vs. HG [20mM] in cells transfected with scrambled siRNA. © 2013 S. Karger AG, Basel - CC BY-NC 3.0

Nm23-H1 Regulates Glucose-Stimulated Insulin Secretion in Pancreatic β-Cells via Arf6-Rac1 Signaling Axis Cell Physiol Biochem 2013;32:533-541 - DOI:10.1159/000354457 Fig. 2. siRNA-mediated knockdown of nm23-H1 markedly inhibits the ability of glucose to activate Arf6 in INS-1 832/13 cells. Glucose-induced Arf6 activation was quantitated in INS-1 832/13 cells transfected with either scrambled [-] or siRNA-nm23-H1 [+] as shown [see Methods for additional details]. Data are mean ± SEM from 3 determinations. * p<0.05 vs LG [5mM], and ** vs. HG [20mM] in cells transfected with scrambled siRNA. © 2013 S. Karger AG, Basel - CC BY-NC 3.0

Nm23-H1 Regulates Glucose-Stimulated Insulin Secretion in Pancreatic β-Cells via Arf6-Rac1 Signaling Axis Cell Physiol Biochem 2013;32:533-541 - DOI:10.1159/000354457 Fig. 3. Inactive mutants of nm23-H1 inhibit glucose-induced membrane association of Rac1 and insulin secretion in INS-1 832/13 cells. Glucose-induced translocation and membrane association was measured in INS-1 832/13 cells transfected with either WT or inactive mutants of nm23-H1 as indicated. Data are expressed as Rac1:actin ratios, and are mean ± SEM from 3 determinations. * p<0.05 vs. LG, and ** not significant vs. LG. © 2013 S. Karger AG, Basel - CC BY-NC 3.0

Nm23-H1 Regulates Glucose-Stimulated Insulin Secretion in Pancreatic β-Cells via Arf6-Rac1 Signaling Axis Cell Physiol Biochem 2013;32:533-541 - DOI:10.1159/000354457 Fig. 4. Inactive mutants of nm23-H1 inhibit glucose-induced membrane association of Rac1 and insulin secretion in INS-1 832/13 cells. GSIS was measured in INS-1 832/13 cells transfected with either WT or inactive mutants of nm23-H1 as indicated. Data are mean ± SEM from 3 determinations. * p<0.05 vs. LG under respective experimental conditions, and ** p<0.05 vs. HG in mock or WT transfected cells. © 2013 S. Karger AG, Basel - CC BY-NC 3.0