A. B. BxPC-3 PANC-1 140 48 h 140 72 h 120 24 h 120 96 h 100 48 h 100 *** * 72 h Cell viability (%) 80 * * Cell viability (%) 80 * * 60 * *

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A. B. BxPC-3 PANC-1 140 48 h 140 72 h 120 24 h 120 96 h 100 48 h 100 *** * 72 h Cell viability (%) 80 *** *** Cell viability (%) 80 *** *** 60 *** *** 60 ** *** *** *** *** 40 *** *** *** 40 *** *** *** *** 20 20 *** *** *** *** *** *** *** *** 0.2 0.4 0.6 0.8 1 0.25 0.5 1 2.5 5 AR-42 (μM) AR-42 (μM) Fig S1. Effects of AR-42 on cell viability of 2 pancreatic cancer cell lines. MTT assay analyzing the effect of AR-42 on (A) BxPC-3 and (B) PANC-1 cell viability. The IC50 of AR-42 for BxPC-3 were 0.74, 0.52, 0.29 μM at 24, 48, and 72 h, respectively. The IC50 of AR-42 for PANC-1 were 0.67 and 0.18 μM at 72 and 96 h, respectively. The inhibition of PANC-1 cell viability did not reach 50% at 48 h. Data are presented as mean ± S.D. from three individual experiments. * P < 0.05, ** P < 0.01, *** P < 0.001 compared to the control group.