From: High Glucose Induces Mitochondrial Dysfunction in Retinal Müller Cells: Implications for Diabetic Retinopathy Invest. Ophthalmol. Vis. Sci.. 2017;58(7):2915-2921.

Slides:

Advertisements

Similar presentations

Invest. Ophthalmol. Vis. Sci ;49(10): doi: /iovs Figure Legend:

Advertisements

Invest. Ophthalmol. Vis. Sci ;49(10): doi: /iovs Figure Legend:

Invest. Ophthalmol. Vis. Sci ;49(10): doi: /iovs Figure Legend:

From: Enhanced Motion Aftereffects in Migraine Are Related to Contrast Sensitivity: Implications for Models of Differences in Precortical/Cortical Function.

From: Postnatal Gene Expression in the Normal Mouse Cornea by SAGE

From: Downregulation of PTEN at Corneal Wound Sites Accelerates Wound Healing through Increased Cell Migration Invest. Ophthalmol. Vis. Sci ;52(5):

Invest. Ophthalmol. Vis. Sci ;52(1): doi: /iovs Figure Legend:

Invest. Ophthalmol. Vis. Sci ;54(3): doi: /iovs Figure Legend:

From: Lectin from Agaricus bisporus Inhibited S Phase Cell Population and Akt Phosphorylation in Human RPE Cells Invest. Ophthalmol. Vis. Sci ;53(12):

From: Targeted Administration into the Suprachoroidal Space Using a Microneedle for Drug Delivery to the Posterior Segment of the Eye Invest. Ophthalmol.

From: Inhibition of Apoptosis and Reduction of Intracellular pH Decrease in Retinal Neural Cell Cultures by a Blocker of Carbonic Anhydrase Invest. Ophthalmol.

From: Experimental Anterior Ischemic Optic Neuropathy in Diabetic Mice Exhibited Severe Retinal Swelling Associated With VEGF Elevation Invest. Ophthalmol.

From: Development of a Rat Schematic Eye From In Vivo Biometry and the Correction of Lateral Magnification in SD-OCT Imaging Invest. Ophthalmol. Vis. Sci..

From: A Murine Model for Retinopathy of Prematurity Identifies Endothelial Cell Proliferation as a Potential Mechanism for Plus Disease Invest. Ophthalmol.

Invest. Ophthalmol. Vis. Sci ;48(4): doi: /iovs Figure Legend:

Invest. Ophthalmol. Vis. Sci ;45(6): doi: /iovs Figure Legend:

Invest. Ophthalmol. Vis. Sci ;48(1): doi: /iovs Figure Legend:

From: Artificial Polymeric Scaffolds as Extracellular Matrix Substitutes for Autologous Conjunctival Goblet Cell Expansion Invest. Ophthalmol. Vis. Sci..

From: Klf4 Regulates the Expression of Slurp1, Which Functions as an Immunomodulatory Peptide in the Mouse Cornea Invest. Ophthalmol. Vis. Sci ;53(13):

From: Effect of Mandarin Orange Yogurt on Allergic Conjunctivitis Induced by Conjunctival Allergen Challenge Invest. Ophthalmol. Vis. Sci ;58(7):

From: Quantification of Oxygen Consumption in Retina Ex Vivo Demonstrates Limited Reserve Capacity of Photoreceptor Mitochondria Invest. Ophthalmol. Vis.

From: Morphometric Changes in the Rat Optic Nerve Following Short-term Intermittent Elevations in Intraocular Pressure Invest. Ophthalmol. Vis. Sci ;51(12):

Figure Legend: From: Lymphatic Markers in the Adult Human Choroid

From: Fundus Camera-Delivered Light-Induced Retinal Degeneration in Mice With the RPE65 Leu450Met Variant is Associated With Oxidative Stress and Apoptosis.

Invest. Ophthalmol. Vis. Sci ;49(4): doi: /iovs Figure Legend:

From: Phenotypes and Biomarkers of Diabetic Retinopathy

Invest. Ophthalmol. Vis. Sci ;50(11): doi: /iovs Figure Legend:

From: Effect of Cataract Surgery on Optical Coherence Tomography Measurements and Repeatability in Patients With Non-Insulin–Dependent Diabetes Mellitus.

From: Hypoxic-Preconditioned Bone Marrow Stem Cell Medium Significantly Improves Outcome After Retinal Ischemia in Rats Invest. Ophthalmol. Vis. Sci..

From: Effects of Sildenafil and Tadalafil on Intraocular Pressure in Sheep: Implications for Aqueous Humor Dynamics Invest. Ophthalmol. Vis. Sci ;51(6):

Figure Legend: From: High-Fat Diet–Induced Retinal Dysfunction

From: Role of Caveolin-1 for Blocking the Epithelial-Mesenchymal Transition in Proliferative Vitreoretinopathy Invest. Ophthalmol. Vis. Sci ;58(1):

From: Wnt/β-Catenin Signaling Mediates Regeneration of Retinal Pigment Epithelium After Laser Photocoagulation in Mouse Eye Invest. Ophthalmol. Vis. Sci..

From: Evaluation of Corneal Displacement Using High-Speed Photography at the Early and Late Phases of Noncontact Tonometry Invest. Ophthalmol. Vis. Sci..

From: One-Year Outcome of 49-Channel Suprachoroidal–Transretinal Stimulation Prosthesis in Patients With Advanced Retinitis Pigmentosa Invest. Ophthalmol.

From: Mitochondrial Dynamics Regulate Growth Cone Motility, Guidance, and Neurite Growth Rate in Perinatal Retinal Ganglion Cells In Vitro Invest. Ophthalmol.

From: Changes in the Photoreceptor Mosaic of P23H-1 Rats During Retinal Degeneration: Implications for Rod-Cone Dependent Survival Invest. Ophthalmol.

From: Serum Deprivation Induces Apoptotic Cell Death of Transformed Rat Retinal Ganglion Cells via Mitochondrial Signaling Pathways Invest. Ophthalmol.

From: Defective Angiogenesis and Intraretinal Bleeding in Mouse Models With Disrupted Inner Retinal Lamination Invest. Ophthalmol. Vis. Sci ;57(4):

Invest. Ophthalmol. Vis. Sci ;45(3): doi: /iovs Figure Legend:

From: Migration of Toxoplasma gondii –Infected Dendritic Cells across Human Retinal Vascular Endothelium Invest. Ophthalmol. Vis. Sci ;53(11):

Invest. Ophthalmol. Vis. Sci ;52(8): doi: /iovs Figure Legend:

From: An Experimental Protocol of the Model to Quantify Traction Applied to the Retina by Vitreous Cutters Invest. Ophthalmol. Vis. Sci ;51(8):

From: Experimental Glaucoma and Optic Nerve Transection Induce Simultaneous Upregulation of Proapoptotic and Prosurvival Genes Invest. Ophthalmol. Vis.

Invest. Ophthalmol. Vis. Sci ;54(4): doi: /iovs Figure Legend:

From: Epigenetic Modification of Sod2 in the Development of Diabetic Retinopathy and in the Metabolic Memory: Role of Histone Methylation Invest. Ophthalmol.

From: In Vivo Imaging of Microscopic Structures in the Rat Retina

From: Construction of an Inexpensive, Hand-Held Fundus Camera through Modification of a Consumer “Point-and-Shoot” Camera Invest. Ophthalmol. Vis. Sci..

Invest. Ophthalmol. Vis. Sci ;57(6): doi: /iovs Figure Legend:

From: Mesenchymal Stem Cells Ameliorate Experimental Autoimmune Uveoretinitis by Comprehensive Modulation of Systemic Autoimmunity Invest. Ophthalmol.

From: Glycerol Monolaurate Inhibits Lipase Production by Clinical Ocular Isolates Without Affecting Bacterial Cell Viability Invest. Ophthalmol. Vis. Sci..

Invest. Ophthalmol. Vis. Sci ;53(13): doi: /iovs Figure Legend:

From: Two-Photon Autofluorescence Imaging Reveals Cellular Structures Throughout the Retina of the Living Primate Eye Invest. Ophthalmol. Vis. Sci ;57(2):

From: A High-Throughput Biophotonics Instrument to Screen for Novel Ocular Photosensitizing Therapeutic Agents Invest. Ophthalmol. Vis. Sci ;51(5):

From: VEGF Antagonists Decrease Barrier Function of Retinal Pigment Epithelium In Vitro: Possible Participation of Intracellular Glutathione Invest. Ophthalmol.

Retinoblastoma Treatment: Utilization of the Glycolytic Inhibitor, 2-deoxy-2-fluoro-d-glucose (2-FG), to Target the Chemoresistant Hypoxic Regions in LHBETATAG.

Invest. Ophthalmol. Vis. Sci ;57(2): doi: /iovs Figure Legend:

From: Higher Contrast Requirement for Letter Recognition and Macular RGC+ Layer Thinning in Glaucoma Patients and Older Adults Invest. Ophthalmol. Vis.

From: Silencing of the CHM Gene Alters Phagocytic and Secretory Pathways in the Retinal Pigment Epithelium Invest. Ophthalmol. Vis. Sci ;51(2):

From: Diffusion Tensor Imaging Detected Optic Nerve Injury Correlates with Decreased Compound Action Potentials after Murine Retinal Ischemia Invest. Ophthalmol.

From: Phototoxicity of Indocyanine Green under Continuous Fluorescent Lamp Illumination and Its Prevention by Blocking Red Light on Cultured Müller Cells.

From: Quantifying Microvascular Density and Morphology in Diabetic Retinopathy Using Spectral-Domain Optical Coherence Tomography Angiography Invest. Ophthalmol.

From: Pressure-Induced Regulation of IL-6 in Retinal Glial Cells: Involvement of the Ubiquitin/Proteasome Pathway and NFκB Invest. Ophthalmol. Vis. Sci..

From: Progressive Myopia or Hyperopia Can Be Induced in Chicks and Reversed by Manipulation of the Chromaticity of Ambient Light Invest. Ophthalmol. Vis.

From: High Resolution OCT Quantitative Analysis of the Space Between the IOL and the Posterior Capsule During the Early Cataract Postoperative Period Invest.

From: Development and Characterization of an Adult Retinal Explant Organotypic Tissue Culture System as an In Vitro Intraocular Stem Cell Transplantation.

Invest. Ophthalmol. Vis. Sci ;54(2): doi: /iovs Figure Legend:

From: Retinal Structure of Birds of Prey Revealed by Ultra-High Resolution Spectral-Domain Optical Coherence Tomography Invest. Ophthalmol. Vis. Sci..

From: Cellular Reorganization in the Human Retina during Normal Aging

Invest. Ophthalmol. Vis. Sci ;55(7): doi: /iovs Figure Legend:

Presentation transcript:

From: High Glucose Induces Mitochondrial Dysfunction in Retinal Müller Cells: Implications for Diabetic Retinopathy Invest. Ophthalmol. Vis. Sci.. 2017;58(7):2915-2921. doi:10.1167/iovs.16-21355 Figure Legend: Mitochondrial membrane potential heterogeneity. Increase in mitochondrial membrane potential heterogeneity of rMC-1 grown in HG for 7 days. (A) Rat retinal Müller cells grown for 7 days in N or HG medium were double stained with mitochondrial membrane potential-sensitive TMRE (red) dye and membrane potential-independent MTG (green) dye. Mitochondria of rMC-1 grown in N medium are uniformly yellow, indicating little variation in membrane potential among the mitochondrial population, whereas mitochondria of rMC-1 grown in HG medium showed a greater variance in color (yellow, green, orange), indicating varied uptake of TMRE and heterogenic membrane potential within the mitochondrial network. Scale bars: 5 μm. (B) The graph shows the SD of the membrane potentials indicating significant increase in the heterogeneity of mitochondrial membrane potential. *P < 0.0005, n = 9. Date of download: 10/29/2017 The Association for Research in Vision and Ophthalmology Copyright © 2017. All rights reserved.