U05-16267
Clinical History Mr. N S-T 18 year old male presented with one to two month history of general malaise and a more recent onset of nasal congestion, red eyes joint and muscle pain. Seen by GP; Creatinine = 380 .... Urgent referral.
Clinical History ARF Creat = 350 Active urine sediment with red cell casts Episclerittis/uveitis Joint pains ?RPGN ?SLE – serology pending
BIOPSY
Immunofluorescence IgG – Negative IgA – Negative IgM – Negative C3 – Mild mesangial C1q – Negative Kappa – Negative Lambda – Negative Fibrinogen – Negative Albumin – Mild hyaline droplet change in tubular cytoplasm
C3
Albumin
EM
Diagnosis: Concentric and Necrotizing Glomerulonephritis of pauci-immune character