Design, study quality and evidence of analgesic efficacy in studies of drugs in models of OA pain: a systematic review and a meta-analysis A.K. Suokas,

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Presentation transcript:

Design, study quality and evidence of analgesic efficacy in studies of drugs in models of OA pain: a systematic review and a meta-analysis A.K. Suokas, D.R. Sagar, P.I. Mapp, V. Chapman, D.A. Walsh Osteoarthritis and Cartilage Volume 22, Issue 9, Pages 1207-1223 (September 2014) DOI: 10.1016/j.joca.2014.06.015 Copyright © 2014 Osteoarthritis Research Society International Terms and Conditions

Fig. 1 Flow diagram of study selection. Osteoarthritis and Cartilage 2014 22, 1207-1223DOI: (10.1016/j.joca.2014.06.015) Copyright © 2014 Osteoarthritis Research Society International Terms and Conditions

Fig. 2 Pooled SMDs and 95% CIs for the analgesic treatment effect of NSAIDs and opioids, by pain modality. Positive increasing SMDs indicate analgesic efficacy. Thermally-evoked pain with only two observations from one study was excluded from the analysis. One study may involve the testing of more than one pain modality and/or drug. Forest plots for each subgroup are presented in Appendix 5. Osteoarthritis and Cartilage 2014 22, 1207-1223DOI: (10.1016/j.joca.2014.06.015) Copyright © 2014 Osteoarthritis Research Society International Terms and Conditions

Fig. 3 Funnel plot for the magnitude of the analgesic treatment effect (n = 102). Test for publication bias: Egger's test = 5.04 (95% CI = 3.72–6.36) P < 0.0001. Osteoarthritis and Cartilage 2014 22, 1207-1223DOI: (10.1016/j.joca.2014.06.015) Copyright © 2014 Osteoarthritis Research Society International Terms and Conditions

Osteoarthritis and Cartilage 2014 22, 1207-1223DOI: (10. 1016/j. joca Copyright © 2014 Osteoarthritis Research Society International Terms and Conditions

Osteoarthritis and Cartilage 2014 22, 1207-1223DOI: (10. 1016/j. joca Copyright © 2014 Osteoarthritis Research Society International Terms and Conditions

Osteoarthritis and Cartilage 2014 22, 1207-1223DOI: (10. 1016/j. joca Copyright © 2014 Osteoarthritis Research Society International Terms and Conditions

Osteoarthritis and Cartilage 2014 22, 1207-1223DOI: (10. 1016/j. joca Copyright © 2014 Osteoarthritis Research Society International Terms and Conditions

Osteoarthritis and Cartilage 2014 22, 1207-1223DOI: (10. 1016/j. joca Copyright © 2014 Osteoarthritis Research Society International Terms and Conditions

Osteoarthritis and Cartilage 2014 22, 1207-1223DOI: (10. 1016/j. joca Copyright © 2014 Osteoarthritis Research Society International Terms and Conditions