CBZ is the most common antiepileptic drug (AED) causing AED-induced seizure worsening. CBZ can both aggravate and induce new seizure types including absence,

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Presentation transcript:

CBZ is the most common antiepileptic drug (AED) causing AED-induced seizure worsening. CBZ can both aggravate and induce new seizure types including absence, atonic, or myoclonic seizures in patients with generalized epilepsies. Vigabatrin and gabapentin have been found to induce absence and myoclonic seizures. Benzodiazepines have been reported to precipitate tonic seizures in patients with Lennox–Gastaut syndrome. Lamotrigine has been reported to worsen myoclonic, clonic, and tonic-clonic seizures in the patients with Dravet syndrome.1–3 Therefore, “AED-induced seizure worsening” must be considered in all patients whose seizures are worse with the introduction of the new AED. Source: Generalized Epilepsy, Atlas of Pediatric EEG Citation: Laoprasert P. Atlas of Pediatric EEG; 2011 Available at: http://neurology.mhmedical.com/DownloadImage.aspx?image=/data/books/1042/lao001_fig_08-01.gif&sec=59079815&BookID=1042&ChapterSecID=59078730&imagename= Accessed: October 24, 2017 Copyright © 2017 McGraw-Hill Education. All rights reserved