Nonproliferative DR (n=24)

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Presentation transcript:

Nonproliferative DR (n=24) Table 3. Serum concentrations of PON1 and biochemical parameters in patients with proliferative and nonproliferative retinopathy and with DME Nonproliferative DR (n=24) Proliferative DR (n=24) DR with DME (n=17) DR without DME (n=31) p1 p2 PON1 (U/L) 126 (48-288) 59.5 (27-155) 190 (61-288) 62 (27-137) <0.001† HbA1C (%) 8.5±1.80 8.8±1.68 8.05(5.1-13.0) 8.90(6.1-11.0) 0.550‡ 0.588† Triglycerides (mg/dl) 136 (70-312) 138.5 (56-322) 139±70.5 171.2±72.2 0.787† 0.166‡ Total Cholesterol (mg/dl) 197±26.8 210±47.2 192±28.9 213±45.2 0.983‡ HDL (mg/dl) 47±9.06 46.5±6.4 46.8±9.07 46.5±6.47 0.754‡ LDL (mg/dl) 145 (106-258) 155.5 (85-219) 155±42.6 150±30.8 0.879† 0.451‡ NLR 2.59±1.52 2.61 ± 0.80 2.01(1.14-4.36) 2.67(0.78-6.11) 0.421‡ 0.937† Uric acid (mg/dl) 4.8 (3.3-9.5) 5.5 (4.1-9.0) 4.9(3.3-9.5) 5.5(3.8-9.0) 0.251† 0.165† Hcy (umol/L) 14.4 (8.6-40.2) 16.0 (7.35-26.1) 14.2±3.13 17.4±8.28 0.581† 0.492‡ hsCRP (mg/L) 2.6 (1.0-38.6) 2.7 (0.25-10.3) 2.37(0.85-5.46) 3.05(0.25-38.6) 0.606† 0.659† PON:hsCRP ratio 47.9 (2.3-175.6) 25.8(5.49-224.0) 54 (14.7-166.6) 21.2 (2.3-224.0) 0.066† † Mann Whitney U test, ‡ Student’s t test. PON1: Paraoxonase 1 activity DR: Diabetic Retinopathy HDL: High-density lipoprotein LDL: Low-density lipoprotein NLR: Neutrophil-lymphocyte ratio Hcy: Homocysteine, hs-CRP: High-sensitivite CRP DME: Diabetic macular edema p1: Nonproliferative DR vs. Proliferative DR p2: DR with DME vs. DR without DME. Narin NASIROGLU IMGA et al. Low Paraoxonase 1 Activity in Diabetes Mellitus as Predictors of Proliferative Diabetic Retinopathy and Macular Edema. American Journal of Medical Sciences and Medicine, 2016, Vol. 4, No. 4, 77-81. doi:10.12691/ajmsm-4-4-2 © The Author(s) 2015. Published by Science and Education Publishing.