Genetic variation in B cell–activating factor of the TNF family (BAFF) and asthma exacerbations among African American subjects Rajesh Kumar, MD, MS,

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Presentation transcript:

Genetic variation in B cell–activating factor of the TNF family (BAFF) and asthma exacerbations among African American subjects Rajesh Kumar, MD, MS, L. Keoki Williams, MD, MPH, Atsushi Kato, PhD, Edward L. Peterson, PhD, Silvio Favoreto, DDS, PhD, Katie Hulse, PhD, Deli Wang, PhD, Kenneth Beckman, PhD, Shannon Thyne, MD, Michael LeNoir, MD, Kelley Meade, MD, David E. Lanfear, MD, MS, Albert M. Levin, PhD, David Favro, BS, James J. Yang, PhD, Kevin Weiss, MD, MPH, Homer A. Boushey, MD, Leslie Grammer, MD, Pedro C. Avila, MD, Esteban G. Burchard, MD, MPH, Robert Schleimer, PhD Journal of Allergy and Clinical Immunology Volume 130, Issue 4, Pages 996-999.e6 (October 2012) DOI: 10.1016/j.jaci.2012.04.047 Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 BAFF expression in vivo after natural rhinovirus-induced URIs. A, RT-PCR results for BAFF gene copy number in naturally acquired infections. The y-axis represents the BAFF gene copy number. The x-axis represents the timing of the sample in days after cold onset. B, Concentration of BAFF protein in nasal lavage fluid from patients with naturally acquired infections. The y-axis represents the BAFF concentration in picograms per milliliter. The x-axis represents the timing of the sample in days after cold onset. Journal of Allergy and Clinical Immunology 2012 130, 996-999.e6DOI: (10.1016/j.jaci.2012.04.047) Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E1 Linkage disequilibrium plot of SNPs in the BAFF gene. The linkage disequilibrium plot shows a color scheme whereby r2 values are as follows: white corresponds to an r2 value of 0, shades of gray correspond to an r2 value of between 0 and 1, and black corresponds to an r2 value of 1. The numbers in the cells represent the r2 values for each pair of SNPs. Journal of Allergy and Clinical Immunology 2012 130, 996-999.e6DOI: (10.1016/j.jaci.2012.04.047) Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E2 BAFF serum levels by genotype. The y-axis represents BAFF concentrations in picograms per milliliter. The AA group (circles) represents subjects homozygous for the risk allele. The AG group (squares) are heterozygotes. The GG group (triangles) are subjects homozygous for the wild-type allele. Journal of Allergy and Clinical Immunology 2012 130, 996-999.e6DOI: (10.1016/j.jaci.2012.04.047) Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions