Individualized Positron Emission Tomography–Based Isotoxic Accelerated Radiation Therapy Is Cost-Effective Compared With Conventional Radiation Therapy:

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Individualized Positron Emission Tomography–Based Isotoxic Accelerated Radiation Therapy Is Cost-Effective Compared With Conventional Radiation Therapy: A Model- Based Evaluation Mathilda L. Bongers, MSc, Veerle M.H. Coupé, PhD, Dirk De Ruysscher, PhD, MD, Cary Oberije, PhD, Philippe Lambin, PhD, MD, Cornelia A. Uyl-de Groot, PhD International Journal of Radiation Oncology • Biology • Physics Volume 91, Issue 4, Pages 857-865 (March 2015) DOI: 10.1016/j.ijrobp.2014.12.012 Copyright © 2015 Elsevier Inc. Terms and Conditions

Fig. 1 Model structure of the micro-simulation model. From the health state “Alive” patients can develop Dysphagia or Dyspnea during or shortly after radiation therapy treatment. International Journal of Radiation Oncology • Biology • Physics 2015 91, 857-865DOI: (10.1016/j.ijrobp.2014.12.012) Copyright © 2015 Elsevier Inc. Terms and Conditions

Fig. 2 Results of the probabilistic sensitivity analysis showing incremental costs and incremental life years (LYs) (A) and quality-adjusted life-years (QALYs) (B) for positron emission tomography–based isotoxic accelerated radiation therapy treatment (PET-ART) compared with conventional CT-based radiation therapy treatment (CRT). International Journal of Radiation Oncology • Biology • Physics 2015 91, 857-865DOI: (10.1016/j.ijrobp.2014.12.012) Copyright © 2015 Elsevier Inc. Terms and Conditions

Fig. 3 Cost-effectiveness acceptability curve for quality-adjusted life-years (QALYs) and life years (LYs): The probability that positron emission tomography–based isotoxic accelerated radiation therapy treatment is cost-effective compared with conventional CT-based radiation therapy treatment for different threshold values. International Journal of Radiation Oncology • Biology • Physics 2015 91, 857-865DOI: (10.1016/j.ijrobp.2014.12.012) Copyright © 2015 Elsevier Inc. Terms and Conditions