Figure 4. Histologic, immunohistochemical analyses of inflammatory myofibroblastic tumor (IMT) at metastasis diagnosis after complete surgical resection.

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Figure 4. Histologic, immunohistochemical analyses of inflammatory myofibroblastic tumor (IMT) at metastasis diagnosis after complete surgical resection. (A) A sample of the IMT obtained on core needle biopsy shows that the tumor was mainly composed of a conspicuous proliferation of spindle cells arranged in a loose fashion and surrounded by infiltrating inflammatory cells (H&E stain, ×100). (B) Tumor showed increased cellularity and cellular atypia of spindle cells compared to first excisional biopsy. Tumor cells showed high mitotic activity (10 mitoses per 10 high-power field) (H&E stain, ×400). (C) Immunohistochemical analysis shows positive staining for smooth muscle actin (SMA) in the spindle tumor cells (SMA, ×400) and (D) positive staining for Ki-67 in about 40% of the spindle tumor cells (Ki-67, ×400). Figure 4. Histologic, immunohistochemical analyses of inflammatory myofibroblastic tumor (IMT) at metastasis diagnosis after complete surgical resection. (A) A sample of the IMT obtained on core needle biopsy shows that the tumor was mainly composed of a conspicuous proliferation of spindle cells arranged in a loose fashion and surrounded by infiltrating inflammatory cells (H&E . . . J Breast Cancer. 2015 Jun;18(2):200-205. http://dx.doi.org/10.4048/jbc.2015.18.2.200