GC Chemical Characteristics Task Group GREENER CHEMICAL PRODUCTS AND PROCESSES STANDARD GC Chemical Characteristics Task Group presentation to Joint Committee on Greener Chemical Products and Processes American Chemical Society Green Chemistry Institute Washington DC October 20, 2009

Developed list of chemical characteristics STANDARD FOR GREENER CHEMICAL PRODUCTS AND PROCESSES GC CHEMICAL CHARACTERISTICS TASK GROUP Approach Developed list of chemical characteristics Categories Subcategories Criteria, potential route of exposure Examples of tests to inform the criteria Matrix of information needed based on intended application, (e.g., closed process, industrial operations, dispersive use) Developed list of filter criteria Applied filter to chemical criteria to determine if appropriate for this standard at this time

Chemical Characteristic Filter Criteria STANDARD FOR GREENER CHEMICAL PRODUCTS AND PROCESSES GC CHEMICAL CHARACTERISTICS TASK GROUP Chemical Characteristic Filter Criteria 1. Is there an established definition? Definable? 2. Is there a validated test? Measurable? or 3. Is there a generally accepted methodology, calculation, model? 4. Is the test/method commonly done?

3-Tiered Approach 3. Potential Future Considerations STANDARD FOR GREENER CHEMICAL PRODUCTS AND PROCESSES GC CHEMICAL CHARACTERISTICS TASK GROUP 3-Tiered Approach 3. Potential Future Considerations No mention in this Standard Characteristics that may be added to this Standard at some future time (e.g., size – nanomaterials; genomics 2. State-of-the-Science Statement Include text statement in this Standard Evolving characteristics – do not yet fulfill our Filter Criteria (e.g., 14-Day Worm, Endocrine Disrupters) 1. Chemical Characteristics List as a Chemical Characteristic for evaluation in this Standard Characteristics that fulfill 3 of our 4 Filter Criteria

Chemical Characteristic Categories & Subcategories STANDARD FOR GREENER CHEMICAL PRODUCTS AND PROCESSES GC CHEMICAL CHARACTERISTICS TASK GROUP Chemical Characteristic Categories & Subcategories Subcategories A. Physical Safety Fire Reactivity Special B. Human Health Acute Chronic Ecological Impact (includes long-term impacts used in life cycle analyses) Air Water Soil

Chemical Characteristic Categories, Subcategories & Criteria STANDARD FOR GREENER CHEMICAL PRODUCTS AND PROCESSES GC CHEMICAL CHARACTERISTICS TASK GROUP Chemical Characteristic Categories, Subcategories & Criteria A. Physical Safety Subcategories Criteria Fire Reactivity Special Flammability Explosivity Corrosive (metal) Oxidizer Water-Reactive Radioactive

Chemical Characteristic Categories, Subcategories, Criteria & Tests STANDARD FOR GREENER CHEMICAL PRODUCTS AND PROCESSES GC CHEMICAL CHARACTERISTICS TASK GROUP Chemical Characteristic Categories, Subcategories, Criteria & Tests B. Human Health Subcategories Criteria Example Tests Acute Inhalation Dermal Oral IDLH STEL/Ceiling LC50 (inhalation) Odor threshold * LD50 Skin Irritation Eye Irritation LD50 (oral) ARfD * Only applies to small number of chemicals

Chemical Characteristic Categories, Subcategories, Criteria & Tests STANDARD FOR GREENER CHEMICAL PRODUCTS AND PROCESSES GC CHEMICAL CHARACTERISTICS TASK GROUP Chemical Characteristic Categories, Subcategories, Criteria & Tests B. Human Health Subcategories Criteria Example Tests Chronic Subchronic Toxicity Repeat dose (28- or 90-day) Reproductive If triggered by repeat Developmental Effects dose or QSAR Carcinogenicity If on IARC or NTP list or if triggered by repeat dose Neurotoxicity If triggered by repeat dose Sensitization (I, D) Chronic Inhalation RfC, TLV Chronic oral RfD (oral) Mutagenicity Bacterial reverse mutation assay, in vitro cytogenetics

Chemical Characteristic Categories, Subcategories, Criteria & Tests STANDARD FOR GREENER CHEMICAL PRODUCTS AND PROCESSES GC CHEMICAL CHARACTERISTICS TASK GROUP Chemical Characteristic Categories, Subcategories, Criteria & Tests C. Ecological Impact Subcategories Criteria Example Tests Air Persistence Bioaccumulation Exposure/Fate Toxicity Long-term Effects Persistence (Air) Half-Life N/A – No Air Test(s) Available Fugacity with Volatilization (VP) Acidification Global Warming Potential Ozone-Depleting Potential Photochemical Smog

Chemical Characteristic Categories, Subcategories, Criteria & Tests STANDARD FOR GREENER CHEMICAL PRODUCTS AND PROCESSES GC CHEMICAL CHARACTERISTICS TASK GROUP Chemical Characteristic Categories, Subcategories, Criteria & Tests C. Ecological Impact Subcategories Criteria Example Tests Water Persistence Bioaccumulation Exposure/Fate Toxicity Long-term Effects EPA Persistence (Water) Half-Life, or Biodegradability & Hydrolysis Half-Lives Log Kow, or BCF, or BAF Fugacity with Water Solubility Fish LC50 Daphnae LC50 Green Algae EC50 Eutrophication Theoretical Oxygen Demand, or Biological Oxygen Demand, or Chemical Oxygen Demand

Chemical Characteristic Categories, Subcategories, Criteria & Tests STANDARD FOR GREENER CHEMICAL PRODUCTS AND PROCESSES GC CHEMICAL CHARACTERISTICS TASK GROUP Chemical Characteristic Categories, Subcategories, Criteria & Tests C. Ecological Impact Subcategories Criteria Example Tests Soil Persistence Bioaccumulation Exposure/Fate Long-term Effects Persistence (Soil) Half-Life N/A – No Soil Test(s) Available Fugacity with Koc Groundwater Mobility Factor

STANDARD FOR GREENER CHEMICAL PRODUCTS AND PROCESSES GC CHEMICAL CHARACTERISTICS TASK GROUP SUMMARY Standard needs to be practical, usable, and provide relevant information Group has developed a recommended list of chemical characteristics that: Have established definitions, Are measurable using validated tests or are calculable using standard, accepted methods, and Have tests that are done commonly. Provide relevant information from a supplier to his customer.