Kyung Won Kim, MD, PhD, Rachel A

Slides:

Advertisements

Similar presentations

Endoplasmic reticulum stress influences bronchial asthma pathogenesis by modulating nuclear factor κB activation So Ri Kim, MD, PhD, Dong Im Kim, MS, Mi.

Advertisements

Genome-wide association study identifies TH1 pathway genes associated with lung function in asthmatic patients Xingnan Li, PhD, MS, Gregory A. Hawkins,

Serum granzymes and CD30 are increased in children's milk protein sensitive enteropathy and celiac disease Merja T. Augustin, MD, Jorma Kokkonen, MD,

Further replication studies of the EVE Consortium meta-analysis identifies 2 asthma risk loci in European Americans Rachel A. Myers, PhD, Blanca E. Himes,

Sangshin Park, DVM, MPH, PhD, Eun-Hee Lee, PhD, Younglim Kho, PhD

Variants near the HLA complex group 22 gene (HCG22) confer increased susceptibility to late-onset asthma in Japanese populations Yohei Yatagai, MD, PhD,

Katherine A. Drake, PhD, Dara G. Torgerson, PhD, Christopher R

Serum granzymes and CD30 are increased in children's milk protein sensitive enteropathy and celiac disease Merja T. Augustin, MD, Jorma Kokkonen, MD,

A Common Variant in SLC8A1 Is Associated with the Duration of the Electrocardiographic QT Interval Jong Wook Kim, Kyung-Won Hong, Min Jin Go, Sung Soo.

Interaction between IL13 genotype and environmental factors in the risk for allergic rhinitis in Korean children Woo Kyung Kim, MD, PhD, Ji-Won Kwon,

Diagnostic accuracy of fractional exhaled nitric oxide measurement in predicting cough- variant asthma and eosinophilic bronchitis in adults with chronic.

Kyoung-Bok Min, MD, PhD, Jin-Young Min, PhD

Genome-wide association study identifies TH1 pathway genes associated with lung function in asthmatic patients Xingnan Li, PhD, MS, Gregory A. Hawkins,

Hyoung Yoon Chang, MD, PhD, MPH, Dong In Suh, MD, Song-I

Santa Jeremy Ono, BA, PhD, Mark B. Abelson, MD

Ann-Marie M. Schoos, MD, PhD, Jacob D

Asthma-associated polymorphisms in 17q21 influence cord blood ORMDL3 and GSDMA gene expression and IL-17 secretion Anna Lluis, MSc, Michaela Schedel,

Volume 141, Issue 3, Pages e5 (September 2011)

Sunita Sharma, MD, MPH, Xiaobo Zhou, PhD, Derek M

Genome-wide association study of lung function phenotypes in a founder population Tsung-Chieh Yao, MD, PhD, Gaixin Du, MS, Lide Han, PhD, Ying Sun, MS,

Lucia Elena Alvarado Arnez, BS, Evaristo N

Variants near the HLA complex group 22 gene (HCG22) confer increased susceptibility to late-onset asthma in Japanese populations Yohei Yatagai, MD, PhD,

Low vitamin D levels are associated with atopic dermatitis, but not allergic rhinitis, asthma, or IgE sensitization, in the adult Korean population Hui.

Association between genetic variations of vascular endothelial growth factor receptor 2 and atopy in the Korean population Heung-Woo Park, MD, Jong-Eun.

A genome-wide association study to identify genetic determinants of atopy in subjects from the United Kingdom Yize I. Wan, BMedSci, David P. Strachan,

Further replication studies of the EVE Consortium meta-analysis identifies 2 asthma risk loci in European Americans Rachel A. Myers, PhD, Blanca E. Himes,

Is 9 more than 2 also in allergic airway inflammation?

Genome-wide interaction study of gene-by-occupational exposure and effects on FEV1 levels Kim de Jong, PhD, Judith M. Vonk, PhD, Wim Timens, PhD, Yohan.

Smoking and risk of psoriasis: A nationwide cohort study

Albert M. Levin, PhD, Rasika A

Katherine A. Drake, PhD, Dara G. Torgerson, PhD, Christopher R

Identification of a new locus at 16q12 associated with time to asthma onset Chloé Sarnowski, PhD, Pierre-Emmanuel Sugier, MSc, Raquel Granell, PhD, Debbie.

BCG vaccination and allergy: A systematic review and meta-analysis

An epigenome-wide association study of total serum IgE in Hispanic children Wei Chen, PhD, Ting Wang, PhD, Maria Pino-Yanes, PhD, Erick Forno, MD, MPH,

S. Melkorka Maggadottir, MD, Jin Li, PhD, Joseph T

IKZF1, a new susceptibility gene for cold medicine–related Stevens-Johnson syndrome/toxic epidermal necrolysis with severe mucosal involvement Mayumi.

Claudin-1 polymorphism modifies the effect of mold exposure on the development of atopic dermatitis and production of IgE Ho-Sung Yu, MS, Mi-Jin Kang,

The nuclear factor I/A (NFIA) gene is associated with the asthma plus rhinitis phenotype Marie-Hélène Dizier, PhD, Patricia Margaritte-Jeannin, PhD,

Genetic risk factors for decreased bone mineral accretion in children with asthma receiving multiple oral corticosteroid bursts Heung-Woo Park, MD, PhD,

Replication of genome-wide association study loci for allergic rhinitis and house dust mite sensitization in an Asian population of ethnic Chinese in.

Peter M. Wolfgram, MD, David B. Allen, MD

Prenatal and postnatal genetic influence on lung function development

CTNNA3 and SEMA3D: Promising loci for asthma exacerbation identified through multiple genome-wide association studies Michael J. McGeachie, PhD, Ann.

Xingnan Li, PhD, Timothy D. Howard, PhD, Siqun L

Maternal microchimerism protects against the development of asthma

Sequencing the IL4 locus in African Americans implicates rare noncoding variants in asthma susceptibility Gabe Haller, BA, Dara G. Torgerson, PhD, Carole.

Genome-wide ancestry association testing identifies a common European variant on 6q14.1 as a risk factor for asthma in African American subjects Dara.

Serum tryptase levels in atopic and nonatopic children

Patterns and predictors of atopic dermatitis disease control past childhood: An observational cohort study Katrina Abuabara, MD, MA, Ole Hoffstad, MS,

Berta Almoguera, PhD, Lyam Vazquez, MD, Frank Mentch, PhD, Michael E

Interaction between IL13 genotype and environmental factors in the risk for allergic rhinitis in Korean children Woo Kyung Kim, MD, PhD, Ji-Won Kwon,

Is eczema really on the increase worldwide?

Role of local CpG DNA methylation in mediating the 17q21 asthma susceptibility gasdermin B (GSDMB)/ORMDL sphingolipid biosynthesis regulator 3 (ORMDL3)

Epigenome-wide association study links site-specific DNA methylation changes with cow's milk allergy Xiumei Hong, MD, PhD, Christine Ladd-Acosta, PhD,

The ANO3/MUC15 locus is associated with eczema in families ascertained through asthma Marie-Hélène Dizier, PhD, Patricia Margaritte-Jeannin, PhD, Anne-Marie.

Michelle Daya, PhD, Kathleen C. Barnes, PhD

Autophagy: Nobel Prize 2016 and allergy and asthma research

Mark Granada, MD, Jemma B. Wilk, DSc, Marina Tuzova, MD, PhD, David P

Inhaled corticosteroid treatment modulates ZNF432 gene variant’s effect on bronchodilator response in asthmatics Ann Chen Wu, MD, MPH, Blanca E. Himes,

Pei-Song Gao, MD, PhD, Nicholas M

Reply Journal of Allergy and Clinical Immunology

Genome-wide association studies of asthma indicate opposite immunopathogenesis direction from autoimmune diseases Xingnan Li, PhD, Elizabeth J. Ampleford,

Genetic predictors associated with improvement of asthma symptoms in response to inhaled corticosteroids Heung-Woo Park, MD, PhD, Amber Dahlin, PhD,

Genetic variants in the GATA3 gene are not associated with asthma and atopic diseases in German children Kathrin Suttner, MSc, Martin Depner, MSc, Norman.

Macrolide antibiotics and asthma treatment

Food allergy is associated with Staphylococcus aureus colonization in children with atopic dermatitis Andrea L. Jones, MD, Douglas Curran-Everett, PhD,

Paradoxical psoriasis following anti–TNF therapy in ankylosing spondylitis: A population- based cohort study Jung Min Bae, MD, PhD, Hyuck Sun Kwon, MD,

Epidermal thymic stromal lymphopoietin predicts the development of atopic dermatitis during infancy Jihyun Kim, MD, PhD, Byung Eui Kim, MD, PhD, Jeongok.

Natural history of cow’s milk allergy

Association study of childhood food allergy with genome-wide association studies– discovered loci of atopic dermatitis and eosinophilic esophagitis Tomomitsu.

Presentation transcript:

Genome-wide association study of recalcitrant atopic dermatitis in Korean children Kyung Won Kim, MD, PhD, Rachel A. Myers, PhD, Ji Hyun Lee, PhD, Catherine Igartua, BS, Kyung Eun Lee, PhD, Yoon Hee Kim, MD, Eun-Jin Kim, PhD, Dankyu Yoon, PhD, Joo-Shil Lee, PhD, Tomomitsu Hirota, DDS, PhD, Mayumi Tamari, MD, PhD, Atsushi Takahashi, PhD, Michiaki Kubo, MD, PhD, Je-Min Choi, PhD, Kyu-Earn Kim, MD, PhD, Dan L. Nicolae, PhD, Carole Ober, PhD, Myung Hyun Sohn, MD, PhD Journal of Allergy and Clinical Immunology Volume 136, Issue 3, Pages 678-684.e4 (September 2015) DOI: 10.1016/j.jaci.2015.03.030 Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 A, Quantile-quantile plot of P values for test statistics (Cochran-Armitage trend tests) in the GWAS. Horizontal and vertical axes show expected P values under a null distribution and observed P values, respectively. Black data points correspond to the P values of all SNPs in the GWAS. B, Manhattan plot showing the −log10P values of 2,501,352 SNPs in the GWAS for 246 Korean children with recalcitrant AD and 551 Korean adult control subjects without a history of allergic diseases and allergic sensitization plotted against their respective positions on the autosomes. The red line shows the genome-wide significance threshold (P = 2.0 × 10−8). The gray line shows the threshold at a P value of 1 × 10−6. Locations of NBAS (2p24.3), THEMIS (6q22.33), GATA3 (10p14), PCDH9 (13q21.31), and SCAPER (15q24.3) loci are indicated. Journal of Allergy and Clinical Immunology 2015 136, 678-684.e4DOI: (10.1016/j.jaci.2015.03.030) Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Regional association plots at the 15q24.3 locus for recalcitrant AD. Significant SNPs are located within SCAPER and include cis-eQTLs for ISL2 in whole blood and for PSTPIP1 in CD14+ monocytes after treatment with LPS for 24 hours. The −log10P value (left y-axis) of each SNP is shown according to its chromosomal position (x-axis). Genetic recombination rates are shown by the blue line, and horizontal arrows indicate locations of genes and direction of transcription. The most associated SNP (labeled by rs number) is shown as a purple circle, and its LD (r2) with all other SNPs is indicated by color. Journal of Allergy and Clinical Immunology 2015 136, 678-684.e4DOI: (10.1016/j.jaci.2015.03.030) Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E1 Box plots comparing total serum IgE levels between cases and control subjects among children. Total serum IgE levels are higher in cases than in control subjects (6.443 ± 1.449 vs 3.260 ± 0.941 ln kU/L, respectively; P = 2.2 × 10−16). Journal of Allergy and Clinical Immunology 2015 136, 678-684.e4DOI: (10.1016/j.jaci.2015.03.030) Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E2 Regional association plots at the 13q21.31 (A), 2p24.3 (B), 6q22.33 (C), and 10p14 (D) loci for recalcitrant AD. For each plot, the −log10P value (left y-axis) of each SNP is shown according to its chromosomal position (x-axis). Genetic recombination rates are shown by the blue line, and horizontal arrows indicate locations of genes and direction of transcription. The most associated SNP (labeled by rs number) is shown as a purple circle, and its LD (r2) with all other SNPs is indicated by color Journal of Allergy and Clinical Immunology 2015 136, 678-684.e4DOI: (10.1016/j.jaci.2015.03.030) Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions