Evaluation of Indomethacin Percutaneous Absorption from Nanostructured Lipid Carriers (NLC): In Vitro and In Vivo Studies Maurizio Ricci, Carmelo Puglia,

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Presentation transcript:

Evaluation of Indomethacin Percutaneous Absorption from Nanostructured Lipid Carriers (NLC): In Vitro and In Vivo Studies Maurizio Ricci, Carmelo Puglia, Francesco Bonina, Caterina Di Giovanni, Stefano Giovagnoli, Carlo Rossi Journal of Pharmaceutical Sciences Volume 94, Issue 5, Pages 1149-1159 (May 2005) DOI: 10.1002/jps.20335 Copyright © 2005 Wiley-Liss, Inc. Terms and Conditions

Figure 1 PCS analysis of the IND loaded NLC. Journal of Pharmaceutical Sciences 2005 94, 1149-1159DOI: (10.1002/jps.20335) Copyright © 2005 Wiley-Liss, Inc. Terms and Conditions

Figure 2 OPC analysis of IND loaded NLC expressed as population number versus particle size. Journal of Pharmaceutical Sciences 2005 94, 1149-1159DOI: (10.1002/jps.20335) Copyright © 2005 Wiley-Liss, Inc. Terms and Conditions

Figure 3 SEM picture of freshly prepared IND loaded NLC. Journal of Pharmaceutical Sciences 2005 94, 1149-1159DOI: (10.1002/jps.20335) Copyright © 2005 Wiley-Liss, Inc. Terms and Conditions

Figure 4 Permeation profiles of indomethacin through SCE membranes from different gel formulations (A–D). (⧫) formulation A; (▪) formulation B; (▴) formulation C; (●) formulation D. Journal of Pharmaceutical Sciences 2005 94, 1149-1159DOI: (10.1002/jps.20335) Copyright © 2005 Wiley-Liss, Inc. Terms and Conditions

Figure 5 Percentage inhibitions (PIE) of UVB-induced erythema by different topical formulations (gel A–D) containing IND (2%). Data represent the mean for ten subjects. Journal of Pharmaceutical Sciences 2005 94, 1149-1159DOI: (10.1002/jps.20335) Copyright © 2005 Wiley-Liss, Inc. Terms and Conditions

Figure 6 Total stratum corneum weight obtained after 20 tape-stripping effected t=1, 3, and 6h from the removal of A–C formulations. Data represent the mean for 10 subjects. Journal of Pharmaceutical Sciences 2005 94, 1149-1159DOI: (10.1002/jps.20335) Copyright © 2005 Wiley-Liss, Inc. Terms and Conditions

Figure 7 Total amount of IND within the tape-stripped stratum corneum after t=1, 3, and 6h from the removal of A–C formulations. Data represent the mean for ten subjects. ND, not detectable. Journal of Pharmaceutical Sciences 2005 94, 1149-1159DOI: (10.1002/jps.20335) Copyright © 2005 Wiley-Liss, Inc. Terms and Conditions