Translational Research

Why should you care about translational research? The public cares. Translation into therapies justifies spending on science. Medical schools care. Discoveries from translation can drive clinical revenue, makes a hospital “cutting edge.” Clinicians care. This is why many physicians choose to work at academic medical centers. Increasing impatience to improve the health of the public. Care about the health of your community.

So where is the tension? Inadequate NIH financial support Progressive decline in the number of physician- scientists Pressure on clinicians to produce clinical income Increased competition to secure post-doc position Pressure on basic scientists to follow a traditional route to secure funding

Remember these guys? Brown and Goldstein, to be exact.

What can YOU do? Learn to define a health problem with as much precision as you do a basic science hypothesis Promote discussion and collaboration among basic scientists, clinical researchers, and clinicians to generate new ideas Develop or learn new methods, which can lead to new projects, fresh directions Take responsibility to define your career

Translational Research Competencies Identify major clinical or public health problems and relevant research questions. Literature critique: Identify, interpret, and critique the state of knowledge regarding a question. Design and write a protocol for clinical and translational research. Research implementation: Identify appropriate study design as to feasibility, efficiency, and bias-free inference. Sources of error: Evaluate reliability, validity and quality assurance.

Core Competencies, continued Use appropriate sample size, power. Apply basic statistical principles. Employ effective information management. Identify, evaluate, and minimize risks to research subjects. Effectively communicate orally and in writing with colleagues and the public. Work effectively with the diverse community. Work effectively within a multidisciplinary research team. Display effective leadership Manage a research project (personnel, budget)

Read a literature other than your own

Communicate daily with people who speak a different scientific language

Practice systems thinking

Get to know the patient, family, stakeholder

Talk to clinicians. How does research affect clinical care?

Find a mentor, or a role model outside your focus “I’m not a role model…Parents should be role models.”

Clinical and Translational Research Education at OHSU - HIP Master of Clinical Research Certificate program (2 years) Focused education in informatics, epidemiology, biostatistics, basic sciences Mentored capstone Certificate in Human Investigations Required didactic coursework (2 years) Non-degree Attend courses in C/T research

HIP Courses of Potential Interest HIP511-3 Clinical Research Design HIP511a Proposal Development HIP 528,9 Applied Biostatistics HIP 512A Biostatistics with STATA HIP 516 Protection of Human Subjects Responsible Conduct of Research HIP 530 Leadership Skills for Team Science HIP 531 Project Management HIP 532 Understanding and Managing in Academic Organizations Scientific Review Practicum HIP 517 Scientific Writing and Data Presentation HIP 527 Systematic Reviews HIP 523 Computerized Data Management HIP 520 Medical Informatics HIP 507A Evidence-Based Medicine HIP 514 Molecular and Cellular Approaches to Disease HIP 534 Health Disparities Research HIP 533 Community-based Research BMI 530/630 Practice of Health Care

OCTRI RESEARCH INFRASTRUCTURE Serving scientists and facilitating partnerships Industry new investigators pilot funds OHSU Partners OCTRI RESEARCH INFRASTRUCTURE research space, biostatistics, informatics, core labs, populations, scientific communities, expertise, coordination

Designing a Study Statistical support with grant submissions, study design, and analysis plans Feasibility analyses using Epic data or ResearchMatch Budget development for grant submissions and clinical trials Consulting with OCTRI experts on data management, laboratory analysis, community-engagement Design Studio www.octri.org/services

Fulfilling Compliance Requirements Compliance preparation and submission − OHSU, VA IRBs − Biosafety, Radiation, and Knight review committees Data Safety Monitoring Plan FWA Assurance for community partners Drug compliance, coordination, and reconciliation www.octri.org/services

Implementing a Study Comprehensive study start-up and coordination services Clinical research facility with skilled research nurses − Experienced study coordinators Laboratory services Bionutrition services for feeding studies Body composition and energy expenditure measurements www.octri.org/services

Contacts OCTRI Services Human Investigations Program OCTRI Research Navigator (Kitt Swartz) Navigator@ohsu.edu Human Investigations Program Karen McCracken mccracke@ohsu.edu Cynthia Morris (morrisc@ohsu.edu)