Journal of the Neurological Sciences

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Journal of the Neurological Sciences Analysis of the association of fluid balance and short-term outcome in traumatic brain injury Zilong Zhao, Dong Wang, Ying Jia, Ye Tian, Yi Wang, Yingsheng Wei, Jianning Zhang, Rongcai Jiang Journal of the Neurological Sciences Volume 364, Pages 12-18 (May 2016) DOI: 10.1016/j.jns.2016.03.007 Copyright © 2016 Terms and Conditions

Fig. 1 Relationship between fluid balance and short-term outcome: Correlations between fluid balance and 30day outcome of patients in low (A) and upper (B) tertiles for fluid balance. (C) Dynamic changes in the low tertile for fluid balance of patients who had improved (solid line) and deteriorated (dot line) 30day outcomes in the first 5days of hospitalization. (D) Dynamic changes over times in 30day outcomes of patients in the upper tertile for fluid balance in the first 5days of hospitalization. Journal of the Neurological Sciences 2016 364, 12-18DOI: (10.1016/j.jns.2016.03.007) Copyright © 2016 Terms and Conditions

Fig. 2 Fluid balance ROC curve for prediction of short-term outcomes: ROC curves for patients in the lower (A) and higher (B) fluid balance group; the successive variations of fluid balance of 837.5mL and 3725mL, respectively, were determined to be the threshold end point to sensitively and specifically predict short-term outcomes (area under the curve [AUC]=0.665, 95% confidence interval [CI]=0.585–0.746 for the lower fluid balance group, P=0.000 and 0.698, 95% confidence interval [CI]=0.620–0.775 for the higher fluid balance group, P=0.000). Journal of the Neurological Sciences 2016 364, 12-18DOI: (10.1016/j.jns.2016.03.007) Copyright © 2016 Terms and Conditions

Fig. 3 Correlation of fluid balance with other parameters: significant correlations of fluid balance with mean Cr (A), and NCCU stay (B), but not with mean ICP (C), mannitol use (D), and hospital stay (E). Journal of the Neurological Sciences 2016 364, 12-18DOI: (10.1016/j.jns.2016.03.007) Copyright © 2016 Terms and Conditions

Fig. 4 Dynamic changes of ICP in three fluid balance groups: ICP changes over time for patients in three tertiles for fluid balance (*P<0.05 for patients in the low tertile vs. those in the moderate tertile; #P<0.05 for patients in the upper tertiles vs. those in the moderate tertile). Journal of the Neurological Sciences 2016 364, 12-18DOI: (10.1016/j.jns.2016.03.007) Copyright © 2016 Terms and Conditions

Supplementary Fig. 1 Comparison of ICP stability s (under 20mmHg) among patients in three tertiles: A. Most patients in the moderate and low tertiles retained their ICPs below 20mmHg (29/38 and 14/23, respectively, shown inside the red frame), while fewer patients in the upper tertile achieved the state. B. The incidence of the stable ICPs (under 20mmHg) of each group. *Significant difference between moderate and upper fluid balance groups (P<0.05). Journal of the Neurological Sciences 2016 364, 12-18DOI: (10.1016/j.jns.2016.03.007) Copyright © 2016 Terms and Conditions