TNM Classification of Malignant Tumours - 8th edition Changes between the 7th and 8th editions December 2016 “We unite the cancer community to reduce.

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TNM Classification of Malignant Tumours - 8th edition Changes between the 7th and 8th editions December 2016 “We unite the cancer community to reduce the global cancer burden, to promote greater equity, and to integrate cancer control into the world health and development agenda.”

The TMN 8th edition is being published in December 2016. TNM-8 The TMN 8th edition is being published in December 2016. The UICC TNM Project has published the 8th Edition of the TNM Classification of Malignant Tumours that comes into effect on January 1, 2017. Since some organizations may not be ready to adopt the new classification, we recommend that the edition of the TNM classification be always included in data reporting The following is a summary of the changes between the 7th and 8th editions of TNM. Major changes are listed and minor changes are identified.

Lung T1 Tumour 3 cm or less T1mi Minimally invasive adenocarcinoma T1a Tumour 1 cm or less T1b Tumour more than 1 cm but not more than 2 cm T1c Tumour more than 2 cm but not more than 3 cm T2 Tumour more than 3 cm but not more than 5 cm; or tumour with any of the following features: Involves main bronchus without involvement of the carina, or invades visceral pleura or associated with atelectasis or obstructive pneumonitis T2a Tumour more than 3 cm but not more than 4 cm T2b Tumour more than 4 cm but not more than 5 cm

Lung T3 Tumour more than 5 cm but not more than 7 cm or directly invades: parietal pleura, chest wall, phrenic nerve, or parietal pericardium; or separate tumour nodule(s) in the same lobe. T4 Tumour more than 7 cm or of any size that invades any of the following: diaphragm, mediastinum, heart, great vessels, trachea, recurrent laryngeal nerve, oesophagus, vertebral body, carina; or separate tumour nodule(s) in a different ipsilateral lobe to the primary N Category- No Change M Category M1a Separate tumour nodule(s) in a contralateral lobe; tumour with pleural or pericardial nodules or malignant pleural or pericardial effusion M1b Single extrathoracic metastasis in a single organ M1c Multiple extrathoracic metastasis in a single or multiple organs

Lung Stage IA T1 N0 M0 Stage IA1 T1mi,T1a N0 M0 Stage IA2 T1b N0 M0 Stage IA3 T1c N0 M0 Stage IB T2a N0 M0 Stage IIA T2b N0 M0 Stage IIB T1a-c, T2a,b N1 M0 T3 N0 M0 Stage IIIA T1a-c, T2a,b N2 M0 T3 N1 T4 N0,N1 M0 Stage IIIB T1a-c, T2a,b N3 M0 T3, T4 N2 M0 Stage IIIC T3, T4 N3 M0 Stage IV Any T Any N M1 Stage IVA Any T Any N M1a,b Stage IVB Any T Any N M1c

Mesothelioma and Thymus Minor change in T1 category Changes in N category Changes in Stage Thymus Please see details in Nicholson AG, Detterbeck FC, Marino M et al. The IASLC/ITMIG thymic epithelial tumors staging project: proposals for the T component for the forthcoming (8th) edition of the TNM classification of malignant tumors. J Thorac Oncol 2014; 9: s73- s80.

Thank you www.uicc.org