Yvan Boutin, PhD, Jacques Hébert, MD

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Presentation transcript:

Suppression of immune response to Lol p I by administration of idiotype Yvan Boutin, PhD, Jacques Hébert, MD Journal of Allergy and Clinical Immunology Volume 95, Issue 3, Pages 751-758 (March 1995) DOI: 10.1016/S0091-6749(95)70182-6 Copyright © 1995 Mosby, Inc. Terms and Conditions

FIG. 1 Immunization schedule. Mice were first pretreated with anti-Lol p I mAb (290A-167) or anti-ferritin mAb (13A-12) and then received Lol p I adsorbed onto alum. Journal of Allergy and Clinical Immunology 1995 95, 751-758DOI: (10.1016/S0091-6749(95)70182-6) Copyright © 1995 Mosby, Inc. Terms and Conditions

FIG. 2 Dose response to immunization of various concentrations of idiotype (290A-167). Levels of aId antibodies to 290A-167 mAb in mice treated with various doses of idiotype mAb (open circles) or control mAb ( solid circle) were measured by direct binding. Groups of five mice, each received nine intraperitoneal injections at weekly intervals. After the last immunization, serum samples were obtained by retro-orbital bleeding and were tested individually (dilution, 1:100) for aId antibody response. Experimental data represent geometric means with standard error. Journal of Allergy and Clinical Immunology 1995 95, 751-758DOI: (10.1016/S0091-6749(95)70182-6) Copyright © 1995 Mosby, Inc. Terms and Conditions

FIG. 3 Binding inhibition of idiotype (290A-167) to rabbit polyclonal aId antibodies by test sera. Groups of five mice, each received nine intraperitoneal injections of 10 μg of idiotype mAb (open circles) or control mAb ( solid circle) at weekly intervals. Test sera were serially diluted. Experimental points represent geometric means with standard error. Journal of Allergy and Clinical Immunology 1995 95, 751-758DOI: (10.1016/S0091-6749(95)70182-6) Copyright © 1995 Mosby, Inc. Terms and Conditions

FIG. 4 Levels of specific IgE anti-Lol p I at weeks 2, 8, 10, 12, and 14 in mice pretreated with 10 μg of idiotype mAb (2) or control mAb (■). Mice (five mice/group) received 2 μg of Lol p I adsorbed onto alum at weeks 9, 11, and 13. Experimental points represent geometric means with standard error. *p ≤ 0.05. Journal of Allergy and Clinical Immunology 1995 95, 751-758DOI: (10.1016/S0091-6749(95)70182-6) Copyright © 1995 Mosby, Inc. Terms and Conditions

FIG. 5 Levels of specific IgG anti-Lol p I at weeks 2, 8, 10, 12, and 14 in mice pretreated with 10 μg of idiotype mAb (2) or control mAb (■). Mice (five mice/group) received 2 μg of Lol p I adsorbed onto alum at weeks 9, 11, and 13. Experimental points represent geometric means with standard error. *p ≤ 0.05. Journal of Allergy and Clinical Immunology 1995 95, 751-758DOI: (10.1016/S0091-6749(95)70182-6) Copyright © 1995 Mosby, Inc. Terms and Conditions