Start the Conversation Prostate Cancer Start the Conversation Us TOO International Prostate Cancer Education & Support Network

Value of Us TOO to Prostate Cancer Community Us TOO educational resources and support services help men and their spouses/partners and families make informed decisions about prostate cancer detection, treatment options and related side effects. Us TOO website (www.ustoo.org) Inspire online communities Toll-free Us TOO Prostate Cancer HelpLine (1-800-808-7866); which includes matching callers with similar survivors or caregivers for peer-to-peer conversations Chapter/support group services & telephone support group Monthly Hot SHEET newsletter Frequent ‘News You Can Use’ updates and articles Educational content – digital and printed Educational events and presentations Awareness/fundraising through special events like the Rochester SEA Blue Ribbon Walk, SEA Blue Chicago Walk & Run walk/run and numerous local events across the country Advocacy initiatives to impact legislation for prostate cancer research funding

What’s a prostate and what does it do? Gland that’s about the size and shape of a walnut Located below the bladder and in front of the rectum Produces a fluid that mixes with sperm

Prostate Cancer Stats Prostate cancer is the most common cancer among men It’s the second most common cause of death from cancer in men (following lung cancer) Nearly 30,000 men die every year from prostate cancer More than 200,000 men are diagnosed every year More than 2 million men in the U.S. are living with a prostate cancer diagnosis That number is estimated to climb to 4 million by 2024

High Risk Factors Age: 97% are men age 50+ and 60% are men 65+ Race - African American men: Have the highest incidence of prostate cancer Are 60 % more likely to develop the disease compared to Caucasian men And more than twice as likely to die from it Genetics: Men with a family history of prostate cancer are at higher risk for developing prostate cancer Veterans: Vietnam & Korean War veterans exposed to Agent Orange (or men exposed to excessive chemicals)

Prostate Cancer Diagnosis Screening for prostate cancer includes: PSA (prostate specific antigen) blood test DRE (digital rectal exam) Biopsy for diagnosis Confusion over inconsistent messages about the value of PSA testing USPSTF Current CMS “Non-Recommended PSA-Based Screening” Increased diagnosis of advanced disease

Gleason Grades Cell formations are graded on a scale of 3 to 5: Grade 5: cancer cells appear as sheets; high-grade cancer/aggressive Grade 4: cancer cells appear poorly differentiated (irregular shapes and combinations)  Grade 3: cancer cells appear moderately differentiated

New 5 Grade Group System Grade Group 1 (Gleason score ≤ 6) Only individual discrete well-formed glands Grade Group 2 (Gleason score 3+4=7) Predominantly well-formed with lesser component of poorly-formed glands Grade Group 3 (Gleason score 4+3=7) Predominantly poorly-formed glands with lesser component of well-formed glands Grade Group 4 (Gleason score 8) Only poorly-formed/fused glands Grade Group 5 (Gleason score 9 to 10) Lacks gland formation

Prostate Cancer Diagnosis Rather than any “quick fix” for prostate cancer, there are many treatment options and related side effects that each patient needs to evaluate Avoid being over-treated or under-treated

Prostate Cancer Treatment Options Active Surveillance Surgery Radiation (external or brachytherapy) Cryotherapy Hormone Therapy Chemotherapy Biotherapy

Initial Treatment Common Side Effects Managing Side Effects Surgery Radiation Common Side Effects Erectile Dysfunction Incontinence

Erectile Dysfunction Incontinence Intimacy Issues Pills Injections Pumps Implants Incontinence Pads Slings Artificial Sphincter

Prostate Cancer Recap Lack of prostate cancer awareness & education about the disease/detection No symptoms until disease is advanced Confusion over PSA testing per USPSTF guidelines Once diagnosed, there’s no single “best” treatment Every treatment has side effects Misnomer that men don’t die from prostate cancer If detected early, it can be cured… There IS a cure for cancer – under the right circumstances!

Find Prostate Cancer Educational Resources & Support Services at www Find Prostate Cancer Educational Resources & Support Services at www.UsTOO.org Thank You!