IMMUNOHISTOCHEMISTRY

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**** *** * **** **** *** Shahriary et al.- Supplementary Figure 4 (a)

Presentation transcript:

IMMUNOHISTOCHEMISTRY technique which allows to achieve a histological picture able to reveal elements exclusively found in a cell or tissue characterizing the function

EMPLOY OF IMMUNOHISTOCHEMISTRY hormonal receptors neoplastic cells proliferating cells oncoproteins

IMMUNOHISTOCHEMICAL DETECTION OF H. PYLORI ADVANTAGE not required demonstration of biochemical features to support histology HANDICAP high cost: not employed in the clinical practice

BrdU (Cahill) and PCNA (Ierardi) LI IN NORMAL STOMACH AND HP GASTRITIS (1994) (%)

BrdU (Cahill) and PCNA (Ierardi) LI IN THE UPPER FOVEOLAR THIRD (%) Controls HP gastritis

H. pylori and gastric carcinogenesis H. pylori and gastric carcinogenesis. Metanalysis of p 53 mutations (Tsuji et al, 1997)

immature cells in upper pit decreased neutral mucins