NIH HIV/AIDS Research Priorities Stacy Carrington-Lawrence Ph.D. Office of AIDS Research National Institutes of Health

National Institutes of Health Office of the Director Office of AIDS Research National Institute of Child Health and Human Development National Institute on Aging National Institute on Alcohol Abuse and Alcoholism National Institute of Allergy and Infectious Diseases National Institute of Arthritis and Musculoskeletal and Skin Diseases National Cancer Institute National Institute on Deafness and Other Communication Disorders National Institute of Dental and Craniofacial Research National Institute of Diabetes and Digestive and Kidney Diseases National Institute on Drug Abuse National Institute of Environmental Health Sciences National Eye Institute National Institute of General Medical Sciences National Heart, Lung, and Blood Institute National Human Genome Research Institute National Institute of Mental Health National Institute of Neurological Disorders and Stroke National Institute of Nursing Research The OAR is responsible for coordinating the scientific, budgetary, legislative, and policy elements of NIH HIV/AIDS Research. National Institute of Biomedical Imaging and Bioengineering National Center for Complementary and Integrative Health John E. Fogarty International Center National Center for Research Resources National Library of Medicine National Center on Minority Health and Health Disparities Warren Grant Magnuson Clinical Center Center for Information Technology Center for Scientific Review DHHS/NIH/OD/OAR

NIH HIV/AIDS Research Portfolio Largest public investment in AIDS research in the world ($3.0 Billion in FY 2016) Encompasses nearly all 27 NIH ICs Transcends every area of clinical medicine and basic scientific investigation Multi-IC, multidisciplinary, global Comprehensive program of basic, clinical, and behavioral research and training on HIV infection, associated co-infections (TB, malaria), comorbidities, and other complications AIDS Research budget has remained essentially flat since 2012 and therefore NIH leadership mandated that the OAR in consultation with the OAR advisory council examine the NIH portfolio and determine areas of highest priority in order to ensure these areas received adequate support in the face of declining AIDS funding.

NIH Overarching AIDS Research Priorities Critical to ensure that NIH AIDS funds are supporting the highest priorities for next 3-5 years: Reduced incidence, including vaccines, microbicides, PrEP, TasP Next generation of HIV therapies with better safety and ease of use Research toward a cure HIV-associated comorbidities and co- infections Cross cutting areas: Basic research, behavioral and social sciences research, health disparities, and training Although each NIH Institute or Center may have Institute specific HIV/AIDS Priorities based on their respective missions, these are overarching NIH priorities that need to be met for all projects that are supported with AIDS specific funds.

High Priority Research Areas For Use of AIDS Funds Reducing incidence of HIV/AIDS including: Developing/testing promising vaccines candidates, microbicide and PrEP candidates Developing and testing innovative delivery methods to mitigate adherence issues Developing, testing, and implementing strategies to improve HIV testing, entry into prevention services, and entry into treatment

High Priority Research Areas For Use of AIDS Funds (continued) Next generation of HIV therapies Treatment regimens that are less toxic with fewer side effects and complications Longer acting Easier to take and adhere to than current regimens Implementation research to ensure Initiation of treatment as soon as diagnosis has been made Retention and engagement in services Achievement and maintenance of optimal prevention and treatment responses

High Priority Research Areas For Use of AIDS Funds (continued) Research toward a cure including:  Developing novel approaches and strategies to identify and eliminate viral reservoirs Basic and clinical research approaches Lifelong remission of HIV infection Studies of viral persistence, latency, reactivation, and eradication HIV-associated comorbidities, coinfections, and complications including Impact of HIV-associated comorbidities, including TB, malignancies; cardiovascular, neurological, and metabolic complications Premature aging associated with long-term HIV disease and antiretroviral therapy

High Priority Cross-Cutting Areas Basic research including studies on HIV transmission, pathogenesis, and immune dysfunction Behavioral and social science research Research to reduce health disparities in incidence and treatment outcomes Training to conduct high priority research

Medium-Priority Research Areas HIV/AIDS is a meaningful component of the project and/or knowledge about HIV is enhanced by the project Project addresses health and social issues clearly linked with HIV Morbidity and mortality Stigma Examines issues in the context of HIV Other infectious pathogens and diseases Non-infectious pathogens and diseases Substance use/addiction Mental health disorders Research focus or primary outcome is not directly HIV, but may inform HIV studies or impact HIV infected individuals

Medium Priority Research Areas (continued) Results will advance HIV treatment or prevention Results provide tools/techniques and/or capacity beneficial to HIV research Includes training and infrastructure development

Innovation New or original ideas including methods, technologies, models, or more effective tools and products. The NIH RePorter is a good resource to find information on what the NIH is currently funding as well as what we have funded in the past.

Realistic Aims

Grantsmanship Proposal should be clear and concise. Check for grammar and spelling and eliminate jargon. Don’t assume the reviewers will know abbreviations and acronyms (spell out or define).

NIH Session at IAS Grantsmanship Strategies and Peer Review Workshop Wednesday, July 26 Room 241 from 16:30-18:00 NIH is hosting a ‘Grantsmanship strategies and peer review workshop’ on Wednesday, July 26 at 4:30 PM. This workshop will provide advice on how to develop a competitive NIH grant application. Several experienced program and review staff from the Office of AIDS Research (OAR), the National Institute of Allergy and Infectious Diseases (NIAID), the Center for Scientific Review (CSR), and the National Institute of Mental Health (NIMH) will be available at this venue to answer your questions.

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