From: Bivalirudin Versus Heparin With or Without Glycoprotein IIb/IIIa Inhibitors in Patients With STEMI Undergoing Primary Percutaneous Coronary Intervention: Pooled Patient-Level Analysis From the HORIZONS-AMI and EUROMAX Trials J Am Coll Cardiol. 2015;65(1):27-38. doi:10.1016/j.jacc.2014.10.029 Figure Legend: (A) Cardiac and noncardiac mortality. (B) Definite or probable stent thrombosis, acute (within the first 24 h), and subacute (24 h to 30 days) landmark analysis. (C) Major bleeding unrelated to CABG. (D) NACE, the composite of all-cause mortality, reinfarction, IDR, stroke, or non-CABG major bleeding. CABG = coronary artery bypass grafting; GPI = glycoprotein IIb/IIIa inhibitor; IDR = ischemia-driven revascularization; NACE = net adverse clinical event(s). Date of download: 9/20/2016 Copyright © The American College of Cardiology. All rights reserved.

From: Bivalirudin Versus Heparin With or Without Glycoprotein IIb/IIIa Inhibitors in Patients With STEMI Undergoing Primary Percutaneous Coronary Intervention: Pooled Patient-Level Analysis From the HORIZONS-AMI and EUROMAX Trials J Am Coll Cardiol. 2015;65(1):27-38. doi:10.1016/j.jacc.2014.10.029 Figure Legend: Bleeding events are those unrelated to CABG. CI = confidence interval; EUROMAX = European Ambulance Acute Coronary Syndrome Angiography; HORIZONS = Harmonizing Outcomes with RevasculariZatiON and Stents; MACE = major adverse cardiovascular event(s); ST = stent thrombosis; TIMI = Thrombolysis In Myocardial Infarction; other abbreviations as in Figure 1. Date of download: 9/20/2016 Copyright © The American College of Cardiology. All rights reserved.

From: Bivalirudin Versus Heparin With or Without Glycoprotein IIb/IIIa Inhibitors in Patients With STEMI Undergoing Primary Percutaneous Coronary Intervention: Pooled Patient-Level Analysis From the HORIZONS-AMI and EUROMAX Trials J Am Coll Cardiol. 2015;65(1):27-38. doi:10.1016/j.jacc.2014.10.029 Figure Legend: The reduction in NACE with bivalirudin was consistent across all examined subgroups. LAD = left anterior descending; PCI = percutaneous coronary intervention; other abbreviations as in Figures 1 and 2. Date of download: 9/20/2016 Copyright © The American College of Cardiology. All rights reserved.

From: Bivalirudin Versus Heparin With or Without Glycoprotein IIb/IIIa Inhibitors in Patients With STEMI Undergoing Primary Percutaneous Coronary Intervention: Pooled Patient-Level Analysis From the HORIZONS-AMI and EUROMAX Trials J Am Coll Cardiol. 2015;65(1):27-38. doi:10.1016/j.jacc.2014.10.029 Figure Legend: Forest plot demonstrates all adverse events, comparing outcomes with heparin plus GPI versus bivalirudin, based on a pooled analysis of the HORIZONS-AMI (Harmonizing Outcomes with RevasculariZatiON and Stents in Acute Myocardial Infarction) and EUROMAX (European Ambulance Acute Coronary Syndrome Angiography) trials. GPI = glycoprotein IIb/IIIa inhibitor; ST = stent thrombosis; TIMI = Thrombolysis In Myocardial Infarction. Date of download: 9/20/2016 Copyright © The American College of Cardiology. All rights reserved.