1. Date of download: 7/8/2016 Copyright © The American College of Cardiology. All rights reserved. From: Benefit of Early Invasive Therapy in Acute Coronary Syndromes: A Meta-Analysis of Contemporary Randomized Clinical Trials J Am Coll Cardiol. 2006;48(7):1319-1325. doi:10.1016/j.jacc.2006.06.050 Relative risk of recurrent unstable angina resulting in rehospitalization for early invasive therapy compared with conservative therapy at a mean follow-up of 13 months. The results show a long-term reduction in recurrent unstable angina from early invasive therapy. Abbreviations as in Figure 1. Figure Legend:

2. Date of download: 7/8/2016 Copyright © The American College of Cardiology. All rights reserved. From: Benefit of Early Invasive Therapy in Acute Coronary Syndromes: A Meta-Analysis of Contemporary Randomized Clinical Trials J Am Coll Cardiol. 2006;48(7):1319-1325. doi:10.1016/j.jacc.2006.06.050 Relative risk of recurrent nonfatal myocardial infarction for early invasive therapy compared with conservative therapy at a mean follow-up of 2 years. The results show a long-term reduction in myocardial infarction from early invasive therapy. Abbreviations as in Figure 1. Figure Legend:

3. Date of download: 7/8/2016 Copyright © The American College of Cardiology. All rights reserved. From: Benefit of Early Invasive Therapy in Acute Coronary Syndromes: A Meta-Analysis of Contemporary Randomized Clinical Trials J Am Coll Cardiol. 2006;48(7):1319-1325. doi:10.1016/j.jacc.2006.06.050 Relative risk of all-cause mortality based on time of angiography and the extent of revascularization. The results show that invasive therapy at a median of 9.3 h does not provide a greater survival advantage compared with angiography at a median of 39.4 h. In contrast, when a large proportion of invasively treated patients relative to conservatively treated patients undergo revascularization by follow-up, there is a strong improvement in late survival. Figure Legend:

4. Date of download: 7/8/2016 Copyright © The American College of Cardiology. All rights reserved. From: Benefit of Early Invasive Therapy in Acute Coronary Syndromes: A Meta-Analysis of Contemporary Randomized Clinical Trials J Am Coll Cardiol. 2006;48(7):1319-1325. doi:10.1016/j.jacc.2006.06.050 Relative risk of all-cause mortality for early invasive therapy compared with conservative therapy as a function of time. The results show a long-term survival benefit from early invasive therapy without an increase in early adverse events. Figure Legend:

5. Date of download: 7/8/2016 Copyright © The American College of Cardiology. All rights reserved. From: Benefit of Early Invasive Therapy in Acute Coronary Syndromes: A Meta-Analysis of Contemporary Randomized Clinical Trials J Am Coll Cardiol. 2006;48(7):1319-1325. doi:10.1016/j.jacc.2006.06.050 Relative risk of all-cause mortality for early invasive therapy compared with conservative therapy at a mean follow-up of 2 years. The results show a long-term survival benefit from early invasive therapy. CI = confidence interval; FRISC-II = Fragmin and Fast Revascularization During Instability in Coronary Disease; ICTUS = Invasive Versus Conservative Treatment in Unstable Coronary Syndromes Investigators; ISAR-COOL = Intracoronary Stenting With Antithrombotic Regimen Cooling Off; RITA-3 = Randomized Intervention Trial of Unstable Angina; RR = relative risk; TIMI-18 = Thrombolysis In Myocardial Infarction-18; TRUCS = Treatment of Refractory Unstable Angina in Geographically Isolated Areas Without Cardiac Surgery; VINO = Value of First Day Coronary Angiography/Angioplasty in Evolving Non–ST-Segment Elevation Myocardial Infarction. Figure Legend: