Date of download: 7/6/2016 Copyright © 2016 SPIE. All rights reserved. (a) Example of optode configuration for simultaneous EEG-fNIRS. (b) Coregistered optode distribution projected onto the scalp: sources/detectors are marked in blue/green, respectively. Figure Legend: From: Multichannel continuous electroencephalography-functional near-infrared spectroscopy recording of focal seizures and interictal epileptiform discharges in human epilepsy: a review Neurophoton. 2016;3(3): doi: /1.NPh

Date of download: 7/6/2016 Copyright © 2016 SPIE. All rights reserved. HbO and HbR concentration changes from baseline in group analysis where all eight temporal lobe seizures from three patients are aligned to seizure onset at time zero. Solid curve shows the medians and errorbars depict the 25th and the 75th pencentiles of concentration changes of the eight seizures at certain time points. Significance level: p<0.05(*) and p<0.001(***). Figure was adapted from Ref. 36. Figure Legend: From: Multichannel continuous electroencephalography-functional near-infrared spectroscopy recording of focal seizures and interictal epileptiform discharges in human epilepsy: a review Neurophoton. 2016;3(3): doi: /1.NPh

Date of download: 7/6/2016 Copyright © 2016 SPIE. All rights reserved. Case study: patient 1, seizure 4. (a) Hemodynamic variations in both the ipsilateral (epileptogenic) side and contralateral temporal lobe. EEG evidence of seizure is visible above the black line. (b) Topographic uncorrected t-statistics during the initial phase of the seizure. Figure Legend: From: Multichannel continuous electroencephalography-functional near-infrared spectroscopy recording of focal seizures and interictal epileptiform discharges in human epilepsy: a review Neurophoton. 2016;3(3): doi: /1.NPh

Date of download: 7/6/2016 Copyright © 2016 SPIE. All rights reserved. Case study: patient 39. (a) Epileptic focus region: right SMA, shadowed). (b) Reconstructed NIRS channel map over gray matter layer of the patient (dorsal view). (c) EEG fragment with markings for right central IEDs. (d) Hemodynamic responses to central IEDs, patient level, one-tailed, 2-D-peak false discovery rate corrected, p<0.05. Solid black circle (radius: 30 mm): epileptogenic focus. Figure Legend: From: Multichannel continuous electroencephalography-functional near-infrared spectroscopy recording of focal seizures and interictal epileptiform discharges in human epilepsy: a review Neurophoton. 2016;3(3): doi: /1.NPh