The oligodendrocyte precursor mitogen PDGF stimulates proliferation by activation of αvβ3 integrins by Wia Baron, Sanford J. Shattil, and Charles ffrench.

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The oligodendrocyte precursor mitogen PDGF stimulates proliferation by activation of αvβ3 integrins by Wia Baron, Sanford J. Shattil, and Charles ffrench ‐ Constant EMBO J. Volume 21(8): April 15, 2002 ©2002 by European Molecular Biology Organization

Effect of different combinations of substrates and growth factors (at suboptimal concentrations) on OP proliferation. Wia Baron et al. EMBO J. 2002;21: ©2002 by European Molecular Biology Organization

Identification of which integrin is responsible for PDGF ‐ AA ‐ mediated enhanced OP proliferation on Vn. (A) OPs were plated on Vn (10 μg/ml) and the ability of integrin ‐ blocking antibodies and blocking RGD peptides to abolish the PDGF ‐ AA (1 ng/ml) ‐ mediated OP... Wia Baron et al. EMBO J. 2002;21: ©2002 by European Molecular Biology Organization

Association of integrin αvβ3 with the PDGFαR in Triton X ‐ 100 ‐ insoluble fractions. Wia Baron et al. EMBO J. 2002;21: ©2002 by European Molecular Biology Organization

The effect of inhibition of different signal transduction pathways on the PDGF ‐ mediated enhanced OP proliferation on Vn. OPs were either left untreated (ctrl) or were pre ‐ exposed to PD (PD, 50 μM), AG1295 (AG, 10 μM), wortmannin (WM, 50 nM), rapamycin... Wia Baron et al. EMBO J. 2002;21: ©2002 by European Molecular Biology Organization

Effect of PKC activation on the proliferative capacity of OPs on Vn. OPs were either left untreated (ctrl, PDGF, PMA) or were pre ‐ exposed to PD (PD, 50 μM), AG1295 (AG, 10 μM), wortmannin (WM, 50 nM) or BIM (0.5 μM) for 30 min at 37°C (in suspension)... Wia Baron et al. EMBO J. 2002;21: ©2002 by European Molecular Biology Organization

The effect of Mn2+ and immoblized integrin antibodies on the proliferative capacity of OPs on Vn. OPs were plated on Vn (indicated by the horizontal bar) or on immobilized integrin antibodies (β1, β3 and β5), and subsequently left untreated (ctrl, beta 1, b... Wia Baron et al. EMBO J. 2002;21: ©2002 by European Molecular Biology Organization

Effect of low levels of PDGF ‐ AA on integrin αvβ3 activation. Wia Baron et al. EMBO J. 2002;21: ©2002 by European Molecular Biology Organization

Model for oligodendrocyte progenitor proliferation. Wia Baron et al. EMBO J. 2002;21: ©2002 by European Molecular Biology Organization