Date of download: 6/18/2016 Copyright © The American College of Cardiology. All rights reserved. From: Efficacy and Safety of Fasudil in Patients With.

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Date of download: 6/18/2016 Copyright © The American College of Cardiology. All rights reserved. From: Efficacy and Safety of Fasudil in Patients With Stable Angina: A Double-Blind, Placebo-Controlled, Phase 2 Trial J Am Coll Cardiol. 2005;46(10): doi: /j.jacc Schematic diagram of the study design. Exercise testing (X) was performed before dosing (trough), 1 h after dosing (peak), and 4 h after dosing of both fasudil and matching placebo tablets. tid = three times daily. Figure Legend:

Date of download: 6/18/2016 Copyright © The American College of Cardiology. All rights reserved. From: Efficacy and Safety of Fasudil in Patients With Stable Angina: A Double-Blind, Placebo-Controlled, Phase 2 Trial J Am Coll Cardiol. 2005;46(10): doi: /j.jacc Patient disposition during the study. Figure Legend:

Date of download: 6/18/2016 Copyright © The American College of Cardiology. All rights reserved. From: Efficacy and Safety of Fasudil in Patients With Stable Angina: A Double-Blind, Placebo-Controlled, Phase 2 Trial J Am Coll Cardiol. 2005;46(10): doi: /j.jacc Changes in exercise treadmill testing duration from baseline at peak for fasudil- (solid bars) and placebo-treated (open bars) patients (mean ± standard deviation). tid = three times daily. Figure Legend:

Date of download: 6/18/2016 Copyright © The American College of Cardiology. All rights reserved. From: Efficacy and Safety of Fasudil in Patients With Stable Angina: A Double-Blind, Placebo-Controlled, Phase 2 Trial J Am Coll Cardiol. 2005;46(10): doi: /j.jacc Changes in mean time to ≥1 mm ST-segment depression from baseline for fasudil- (solid bars) and placebo-treated (open bars) patients. *p = tid = three times daily. Figure Legend:

Date of download: 6/18/2016 Copyright © The American College of Cardiology. All rights reserved. From: Efficacy and Safety of Fasudil in Patients With Stable Angina: A Double-Blind, Placebo-Controlled, Phase 2 Trial J Am Coll Cardiol. 2005;46(10): doi: /j.jacc Improvements in angina by ≥1 Canadian Cardiovascular Society angina class in patients treated with fasudil (solid bars) and placebo (open bars). tid = three times daily. Figure Legend:

Date of download: 6/18/2016 Copyright © The American College of Cardiology. All rights reserved. From: Efficacy and Safety of Fasudil in Patients With Stable Angina: A Double-Blind, Placebo-Controlled, Phase 2 Trial J Am Coll Cardiol. 2005;46(10): doi: /j.jacc Improvement in Seattle Angina Questionnaire score. (A) Physical limitation scale. (B) Treatment satisfaction scale. *p < tid = three times daily. Open bars = placebo; solid bars = fasudil. Figure Legend: