1. Date of download: 7/8/2016 Copyright © The American College of Cardiology. All rights reserved. From: Tolerability and efficacy of carvedilol in patients with New York Heart Association class IV heart failure J Am Coll Cardiol. 1999;33(4):924-931. doi:10.1016/S0735-1097(98)00680-9 Cumulative survival stratified according to baseline New York Heart Association (NYHA) class (NYHA classes I to III have been analyzed as a single group). Figure Legend:

2. Date of download: 7/8/2016 Copyright © The American College of Cardiology. All rights reserved. From: Tolerability and efficacy of carvedilol in patients with New York Heart Association class IV heart failure J Am Coll Cardiol. 1999;33(4):924-931. doi:10.1016/S0735-1097(98)00680-9 Cumulative freedom from adverse reactions stratified according to baseline New York Heart Association (NYHA) class (NYHA classes I to III have been analyzed as a single group). Solid bar indicates initiation and titration of carvedilol. Figure Legend:

3. Date of download: 7/8/2016 Copyright © The American College of Cardiology. All rights reserved. From: Tolerability and efficacy of carvedilol in patients with New York Heart Association class IV heart failure J Am Coll Cardiol. 1999;33(4):924-931. doi:10.1016/S0735-1097(98)00680-9 Change in left ventricular (LV) end-diastolic dimension (solid bar) and end-systolic dimension (hatched bar) after three months of therapy with carvedilol. ∗∗ p < 0.002, ∗∗∗∗ p < 0.0001 compared with baseline. Paired data were obtained in 122 New York Heart Association (NYHA) class I–III patients and 41 class IV patients. Figure Legend:

4. Date of download: 7/8/2016 Copyright © The American College of Cardiology. All rights reserved. From: Tolerability and efficacy of carvedilol in patients with New York Heart Association class IV heart failure J Am Coll Cardiol. 1999;33(4):924-931. doi:10.1016/S0735-1097(98)00680-9 Change in left ventricular fractional shortening (solid bar) and ejection fraction (hatched bar) after 3 months of therapy with carvedilol. ∗∗∗∗ p < 0.0001 compared with baseline. Paired data were obtained in 122 New York Heart Association (NYHA) class I–III patients and 41 class IV patients. Figure Legend:

5. Date of download: 7/8/2016 Copyright © The American College of Cardiology. All rights reserved. From: Tolerability and efficacy of carvedilol in patients with New York Heart Association class IV heart failure J Am Coll Cardiol. 1999;33(4):924-931. doi:10.1016/S0735-1097(98)00680-9 Change in 6-min walk distance after 3 months of therapy with carvedilol. Open circles = New York Heart Association classes I to III (n = 121); solid circles = class IV (n = 39). Figure Legend: