An antiapoptotic role for telomerase RNA in human immune cells independent of telomere integrity or telomerase enzymatic activity by Francesca S. Gazzaniga,

Slides:

Advertisements

Similar presentations

RNA interference in biology and disease by Carol A. Sledz, and Bryan R. G. Williams Blood Volume 106(3): August 1, 2005 ©2005 by American Society.

Advertisements

Mallory Demonch Biol 455 March 24, 2008

Prach Siriviriyakul. Chromosome must be protected.

Cellular Senescence: A Link between Tumor Suppression and Organismal Aging.

Telomeric Noncoding RNA TERRA Is Induced by Telomere Shortening to Nucleate Telomerase Molecules at Short Telomeres Emilio Cusanelli, Carmina Angelica.

Telomerase, Immortalization and Cancer Eric Bankaitis Cancer Bio 169 March 9, 2006 Fig.[9]

Stem cell concepts renew cancer research by John E. Dick Blood Volume 112(13): December 15, 2008 ©2008 by American Society of Hematology.

Replication 4. The End Replication Problem: Telomeres shorten with each S phase Ori DNA replication is bidirectional Polymerases move 5' to 3' Requires.

Telomerase Activity and Expression of Telomerase RNA Component and Telomerase Catalytic Subunit Gene in Cervical Cancer Kenji Nakano, Elizabeth Watney,

By, PALUVAI HARIKRISHNAREDDY. Contents 1.INTRODUCTION. 2. Telomere biology and cancer 2.1 Link between telomere and telomerase 2.2 Telomeres, a multi.

Generating AML-Specific Peripheral Blood Autologous Cytotoxic T-Lymphocytes (CTLs)‏ by Rohtesh S. Mehta, Xiaohua Chen, Antony Jeyaraj, and Paul Szabolcs.

Inhibition of NF-κB induces apoptosis of KSHV-infected primary effusion lymphoma cells by Shannon A. Keller, Elaine J. Schattner, and Ethel Cesarman Blood.

HOXA9 is required for survival in human MLL-rearranged acute leukemias by Joerg Faber, Andrei V. Krivtsov, Matthew C. Stubbs, Renee Wright, Tina N. Davis,

Vaccine site inflammation potentiates idiotype DNA vaccine-induced therapeutic T cell–, and not B cell–, dependent antilymphoma immunity by Hong Qin, Soung-chul.

Telomeres in Stem Cell Research

Box H/ACA Small Ribonucleoproteins

Uncontrolled Wnt signaling causes leukemia

GVHD-associated immunodeficiency: soil or seed?

Do HSCs divide asymmetrically?

MBL: mostly benign lymphocytes, but…

VEGF therapy: risky business for established plaques?

TCR-MHC-peptide(s): in vivo veritas

Triple play of H pylori in ITP

Multiple Myeloma: Interleukin-15 Antagonizes Bone Morphogenetic Protein-Induced Apoptosis and Growth Inhibition. by Magne Rekvig, Anne-Tove Brenne, Torstein.

Fledgling prognostic markers in CLL

by Jonathan M. Gleadle, and Peter J. Ratcliffe

It's all in the timing by Linda J. Bendall Blood

A Clinical Evaluation of the International Lymphoma Study Group Classification of Non-Hodgkin's Lymphoma Blood Volume 89(11): June 1, 1997 ©1997.

Angiopoietin-2 in CLL by Jan A. Burger Blood Volume 116(4):

by Zhenping Zhu Blood Volume 108(6): September 15, 2006

Tax fingerprint in adult T-cell leukemia

A cell by any other name by Narla Mohandas Blood

Mechanisms of HIV-associated lymphocyte apoptosis

Gnawing at Metchnikoff’s paradigm

Cancer Lecture 2.

Control of DNA Replication

Fluorescent neutrophils throw the spotlight on inflammation

Telomerase regulation in HTLV-I infection

by Keren Mizrahi, and Nadir Askenasy

Taking a leaf from the book of oral tolerance

Has the T cell bitten off more than it can chew?

Telomeres and senescence: The history, the experiment, the future

162. Stability of Polymer/Plasmid DNA Complexes In Vitro and In Vivo

Binding of 53BP1 on uncapped telomeres.

DNA-damage (γ-H2AX) and telomere damage–induced foci (TIFs).

by Douglas D. Ross, Judith E. Karp, Tar T. Chen, and L. Austin Doyle

Stage C or not stage C…? by Claire Dearden Blood

Lasker Laurels for Telomerase

Yang et al. SALL4 is a key regulator of survival and apoptosis in human leukemic cells. Blood. 2008;112(3):805–813. Blood Volume 114(14): October.

by Sansana Sawasdikosol, Kristin M. Russo, and Steven J. Burakoff

Volume 19, Issue 12, Pages (June 2017)

Immunotherapy for acute lymphoblastic leukemia: from famine to feast

Telomerase: A target for cancer therapeutics

724. Blood-Derived Endothelial Progenitor Cells Can Be Isolated With a Novel Method of Diluted Whole Blood Incubation with AMD3100-Induced Mobilization.

Experimental Hematology

Purification of Human Telomerase Complexes Identifies Factors Involved in Telomerase Biogenesis and Telomere Length Regulation Dragony Fu, Kathleen Collins

Maintenance of telomere length in AML

Box H/ACA Small Ribonucleoproteins

Strategy for mutant telomere synthesis in human cancer cells.

HoxA9 directly regulates cell cycle control genes.

Volume 42, Issue 3, Pages (May 2011)

Knockdown of endogenous WT-hTER by a short hairpin RNA (siRNA) directed specifically against the human WT telomerase RNA template. Knockdown of endogenous.

Erratum in Ledru et al. Alteration of tumor necrosis factor–α T-cell homeostasis following potent antiretroviral therapy: contribution to the development.

HTERT expression and telomere length in normal somatic cells and precancerous cells. hTERT expression and telomere length in normal somatic cells and precancerous.

Effects of low-level expression of mutant-template telomerase RNA in MCF-7 breast cancer cells. Effects of low-level expression of mutant-template telomerase.

DNA damage foci accumulate at a subset of telomeres in cells expressing a mutant-template telomerase RNA. Immunostaining was done for telomere-protective.

Schematic model of the mechanism of Tak1 protection of HSPC survival.

Possible mechanisms of famillial idiopathic interstitial pneumonia leading to lung fibrosis involves apoptosis caused mainly through chronic endoplasmic.

Initial treatment of CLL: integrating biology and functional status

Presentation transcript:

An antiapoptotic role for telomerase RNA in human immune cells independent of telomere integrity or telomerase enzymatic activity by Francesca S. Gazzaniga, and Elizabeth H. Blackburn Blood Volume 124(25): December 11, 2014 ©2014 by American Society of Hematology

hTR overexpression protects from dexamethasone-induced apoptosis independent of telomerase activity. Francesca S. Gazzaniga, and Elizabeth H. Blackburn Blood 2014;124: ©2014 by American Society of Hematology

hTR knockdown induces Bim-mediated apoptosis. Francesca S. Gazzaniga, and Elizabeth H. Blackburn Blood 2014;124: ©2014 by American Society of Hematology

Telomerase knockdown does not induce significant telomere shortening or telomere DNA damage-induced foci (TIFs) in the time frame of this experiment. Francesca S. Gazzaniga, and Elizabeth H. Blackburn Blood 2014;124: ©2014 by American Society of Hematology

hTERT overexpression increases telomerase activity and induces apoptosis. Francesca S. Gazzaniga, and Elizabeth H. Blackburn Blood 2014;124: ©2014 by American Society of Hematology

Overexpression of catalytically inactive hTR mutants protects from hTERT-induced apoptosis. Francesca S. Gazzaniga, and Elizabeth H. Blackburn Blood 2014;124: ©2014 by American Society of Hematology

Two functions for hTR. hTR and hTERT complex to form catalytically active telomerase to maintain telomeres. Francesca S. Gazzaniga, and Elizabeth H. Blackburn Blood 2014;124: ©2014 by American Society of Hematology