A novel small-molecule activator of procaspase-3 induces apoptosis in cancer cells and reduces tumor growth in human breast, liver and gallbladder cancer.

Slides:



Advertisements
Similar presentations
LSD1 Is a Subunit of the NuRD Complex and Targets the Metastasis Programs in Breast Cancer Yan Wang, Hua Zhang, Yupeng Chen, Yimin Sun, Fen Yang, Wenhua.
Advertisements

RIG-I Modulates Src-Mediated AKT Activation to Restrain Leukemic Stemness Xian-Yang Li, Lin-Jia Jiang, Lei Chen, Meng-Lei Ding, He-Zhou Guo, Wu Zhang,
Volume 21, Issue 5, Pages (May 2015)
Molecular and Genetic Properties of Tumors Associated with Local Immune Cytolytic Activity Michael S. Rooney, Sachet A. Shukla, Catherine J. Wu, Gad Getz,
Generation of Haploid Spermatids with Fertilization and Development Capacity from Human Spermatogonial Stem Cells of Cryptorchid Patients Shi Yang, Ping.
Rice OsGL1-1 Is Involved in Leaf Cuticular Wax and Cuticle Membrane Bao-Xiang Qin, Ding Tang, Jian Huang, Ming Li, Xin-Ru Wu, Li-Li Lu, Ke-Jian Wang, Heng-Xiu.
Cancer Metabolism Cell Volume 148, Issue 3, (February 2012) DOI: /j.cell Copyright © 2012 Terms and Conditions Terms and Conditions.
A Novel Protein RLS1 with NB–ARM Domains Is Involved in Chloroplast Degradation during Leaf Senescence in Rice Jiao Bin-Bin, Wang Jian-Jun, Zhu Xu-Dong,
Lin28b Is Sufficient to Drive Liver Cancer and Necessary for Its Maintenance in Murine Models Liem H. Nguyen, Daisy A. Robinton, Marc T. Seligson, Linwei.
The Good Fat Cell Volume 147, Issue 7, (December 2011) DOI: /j.cell Copyright © 2011 Terms and Conditions Terms and Conditions.
Cell Traction Forces Direct Fibronectin Matrix Assembly Christopher A. Lemmon, Christopher S. Chen, Lewis H. Romer Biophysical Journal Volume 96, Issue.
High-throughput screens identify microRNAs essential for HER2 positive breast cancer cell growth Suvi-Katri Leivonen, Kristine Kleivi Sahlberg, Rami Mäkelä,
Lung Adenocarcinoma with Ipsilateral Breast Metastasis: A Simple Coincidence? Hsu-Ching Huang, MD, Jen-Fan Hang, MD, Mei-Han Wu, MD, Teh-Ying Chou, MD,
Sialyl Tn-expressing bladder cancer cells induce a tolerogenic phenotype in innate and adaptive immune cells Mylène A. Carrascal, Paulo F. Severino, M.
Hepatic Vascular Endothelial Growth Factor Regulates Recruitment of Rat Liver Sinusoidal Endothelial Cell Progenitor Cells Lin Wang, Xiangdong Wang, Lei.
Primary Small Cell Carcinoma of the Esophagus Jima Lv, MD, Jun Liang, MD, Jinwan Wang, MD, Luhua Wang, MD, Jie He, MD, Zefen Xiao, MD, Weibo Yin, MD Journal.
MicroRNA-302/367 Cluster Governs hESC Self-Renewal by Dually Regulating Cell Cycle and Apoptosis Pathways Zhonghui Zhang, Yuanfan Hong, Di Xiang, Pei Zhu,
Design and Multiseries Validation of a Web-Based Gene Expression Assay for Predicting Breast Cancer Recurrence and Patient Survival Ryan K. Van Laar The.
Nanoparticle mediated silencing of DNA repair sensitizes pediatric brain tumor cells to γ- irradiation Forrest M. Kievit, Zachary R. Stephen, Kui Wang,
A rare complication of Meckel's diverticulum: A fistula between Meckel's diverticulum and the appendix Ping-Fu Yang, Chau-Yun Chen, Fang-Jung Yu, Sheau-Fang.
Different Types of Ground Glass Hepatocytes in Chronic Hepatitis B Virus Infection Contain Specific Pre-S Mutants that May Induce Endoplasmic Reticulum.
Development of Renal Cysts after Crizotinib Treatment in Advanced ALK-Positive Non– Small-Cell Lung Cancer Yen-Ting Lin, MD, Yu-Fen Wang, MD, James Chih-Hsin.
Association between the diagnosis-to-treatment interval and overall survival in Taiwanese patients with oral cavity squamous cell carcinoma  Chun-Ta Liao,
Jung-Mei Tsai, Yu-Hung Wu, Shu Yu, Jiun-Yi Li, Mary Jeanne Buttrey 
Pancreatic Fusion Abnormality Found During a Whipple Procedure
Cancer: Inappropriate Expression of Stem Cell Programs?
Next Generation Sequencing Uncovers Potential Genetic Driver Mutations of Malignant Pulmonary Granular Cell Tumor  Song Xu, Qingchun Zhao, Sen Wei, Yi.
Volume 23, Issue 2, Pages (June 2016)
Volume 25, Issue 4, Pages (April 2014)
High prevalence of azithromycin resistance to Treponema pallidum in geographically different areas in China  X.-S. Chen, Y.-P. Yin, W.-H. Wei, H.-C. Wang,
Perioperative versus Preoperative Chemotherapy with Surgery in Patients with Resectable Squamous Cell Carcinoma of Esophagus  Yang Zhao, MD, ZhiJun Dai,
Volume 17, Issue 9, Pages (September 2009)
Yang Lei, Li Lu, Hai-Yang Liu, Sen Li, Feng Xing, Ling-Ling Chen 
Volume 74, Issue 6, Pages (December 2018)
Pancreatic Fusion Abnormality Found During a Whipple Procedure
Molecular Therapy - Nucleic Acids
Volume 84, Issue 1, Pages (July 2013)
Gastroenterology news
Henry van den Bedem, Ellen Kuhl  Biophysical Journal 
Folate Receptor–Positive Circulating Tumor Cell Detected by LT-PCR–Based Method as a Diagnostic Biomarker for Non–Small-Cell Lung Cancer  Xiaoxia Chen,
Development of a simplified Chinese version of the hip disability and osteoarthritis outcome score (HOOS): cross-cultural adaptation and psychometric.
Prognostic Value of Vascular Endothelial Growth Factor Expression in Patients with Lung Cancer: A Systematic Review with Meta-Analysis  Ping Zhan, MD,
220. AAV-Mediated miR122 Overexpression Rescues Hepatic Inflammatory Response Induced by Acute Iron-Overload  Min Li, Yuxiao Tang, Lusha Wu, Fengfeng.
Expression of growth differentiation factor-9 and bone morphogenetic protein-15 in oocytes and cumulus granulosa cells of patients with polycystic ovary.
Volume 50, Issue 2, Pages (April 2013)
Volume 26, Issue 2, Pages (February 2018)
Multiple Pulmonary Chondromas in a Young Female Patient: A Component of Carney Triad  Gui-Bin Qiao, MD, PhD, Wei-Sheng Zeng, MD, Li-Jun Peng, MD, Wen-Zhao.
Surgical Treatment of a Giant Symptomatic Cardiac Lipoma
The Bony Side of Endothelial Cells in Prostate Cancer
P. Yuan, X. Zhang, W. Yang, W. Kang, B. Yang, J. li, B. Chen, X. Li, B
Liang Wang, MD, Jeremiah A. Aakre, BS, Ruoxiang Jiang, BS, Randolph S
724. Blood-Derived Endothelial Progenitor Cells Can Be Isolated With a Novel Method of Diluted Whole Blood Incubation with AMD3100-Induced Mobilization.
MA17.03 Identifying Genomic Alteration and Inter-Tumor Heterogeneity of Multiple Primary Lung Cancers by Targeted NGS of Tumor Tissue and ctDNA  Kezhong.
Volume 16, Issue 2, Pages (February 2015)
847. Eradication of Therapy-Resistant Human Prostate Tumors Using an Ultrasound Guided Site-Specific Cancer Terminator Virus Delivery Approach    Molecular.
Chemokines in the Biology of Lung Cancer
Volume 143, Issue 6, (December 2010)
JCSE01.16 Positive Correlation Between Whole Genomic Copy Number Variant Scoring and the Grading System in Lung Non-Mucinous Invasive Adenocarcinoma 
Haploidentical/Mismatched Hematopoietic Stem Cell Transplantation without In Vitro T Cell Depletion for T Cell Acute Lymphoblastic Leukemia  Yu Wang,
Mirror Mirror on the Wall, Who Is the Fairest of Them All
674. Molecular, Biochemical and Biomechanical Analysis of Articular Cartilage Repaired with Genetically Modified Chondrocytes Expressing Insulin-Like.
Society for Investigative Dermatology 2010 Meeting Minutes
Reviewer Acknowledgment
The Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand and Lung Cancer: Still Following the Right TRAIL?  Emmet E. McGrath, MB, PhD  Journal of Thoracic.
740. Prevention of Radiation-Induced Lung Injury by Administration of Gene-Modified Mesenchymal Stem Cells    Molecular Therapy  Volume 20, Pages S285-S286.
European Lung Cancer Conference (ELCC) 2016 Organisation
P Combined Molecular and Radiological Evaluation Unveils Three Subtypes of Disease Progression to a Third Generation EGFR TKI  Y. Zhang, Q. Zhou,
Journal of Thoracic Oncology
A Review of First-Line Treatment for Small-cell Lung Cancer
624. Randomized Phase II Trial of Adjuvant Autologous Tumor Cell Vaccine (FANG™) for High Risk Stage III/IV Ovarian Cancer: Preliminary Results    Molecular.
Presentation transcript:

A novel small-molecule activator of procaspase-3 induces apoptosis in cancer cells and reduces tumor growth in human breast, liver and gallbladder cancer xenografts Fangyang Wang, Lihui Wang, Yanfang Zhao, Yi Li, Guanfang Ping, Shu Xiao, Kang Chen, Wufu Zhu, Ping Gong, Jingyu Yang, Chunfu Wu Molecular Oncology Volume 8, Issue 8, Pages (December 2014) DOI: /j.molonc Copyright © 2014 Federation of European Biochemical Societies Terms and Conditions Terms and Conditions

Figure 1 Molecular Oncology , DOI: ( /j.molonc ) Copyright © 2014 Federation of European Biochemical Societies Terms and Conditions Terms and Conditions

Figure 2 Molecular Oncology , DOI: ( /j.molonc ) Copyright © 2014 Federation of European Biochemical Societies Terms and Conditions Terms and Conditions

Figure 3 Molecular Oncology , DOI: ( /j.molonc ) Copyright © 2014 Federation of European Biochemical Societies Terms and Conditions Terms and Conditions

Figure 4 Molecular Oncology , DOI: ( /j.molonc ) Copyright © 2014 Federation of European Biochemical Societies Terms and Conditions Terms and Conditions

Figure 5 Molecular Oncology , DOI: ( /j.molonc ) Copyright © 2014 Federation of European Biochemical Societies Terms and Conditions Terms and Conditions

Supplementary Figure 1 Molecular Oncology , DOI: ( /j.molonc ) Copyright © 2014 Federation of European Biochemical Societies Terms and Conditions Terms and Conditions