Fig Nuclear Receptors

Fig

Shiu et al. (1998) Cell 95: Estrogen Receptor LBD with agonist  -helix from interact- ing co- activator Estrogen Receptor LBD with antagonist Estrogen Tamoxifen

Fig

Fig

 galatosidase -Dex +Dex

-Dex +Dex  galatosidase

Fig

Fig. 4-10

Fig

Fig Signal transduction pathways from extracellular proteins and peptides through cell surface receptors to transcription factors

Fig

N C Histone acetylase domain Domains that interact with activation domains CBP is a multidomain domain protein with several domains that bind to activator activation domains and one histone acetylase domain. It functions as a co-activator for many activators.

CREB Activation domain Domain of CBP

Fig EGF Receptor

Fig

Fig

Fig

Hassler M, Richmond TJ EMBO J. (2001) 20: (TCF)

serum PIC Assembly + serum serum + serum 23 AD

Fig Fos Jun

Nucleus Cytoplasm Plasmamembrane (Immuno- suppresor drugs)