Unbalanced recovery of regulatory and effector T cells after allogeneic stem cell transplantation contributes to chronic GVHD by Ana C. Alho, Haesook T.

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Presentation transcript:

Unbalanced recovery of regulatory and effector T cells after allogeneic stem cell transplantation contributes to chronic GVHD by Ana C. Alho, Haesook T. Kim, Marie J. Chammas, Carol G. Reynolds, Tiago R. Matos, Edouard Forcade, Jennifer Whangbo, Sarah Nikiforow, Corey S. Cutler, John Koreth, Vincent T. Ho, Philippe Armand, Joseph H. Antin, Edwin P. Alyea, Joao F. Lacerda, Robert J. Soiffer, and Jerome Ritz Blood Volume 127(5): February 4, 2016 ©2016 by American Society of Hematology

Reconstitution of major T-cell populations after allogeneic HSCT. The recovery of each T-cell population in peripheral blood was assessed prospectively by flow cytometry. Ana C. Alho et al. Blood 2016;127: ©2016 by American Society of Hematology

Reconstitution of naive and memory T-cell compartments. Ana C. Alho et al. Blood 2016;127: ©2016 by American Society of Hematology

Dynamic profile of CD4Treg subsets. Ana C. Alho et al. Blood 2016;127: ©2016 by American Society of Hematology

Dynamic profile of CD4Tcon subsets. Ana C. Alho et al. Blood 2016;127: ©2016 by American Society of Hematology

Dynamic profile of CD8 T-cell subsets. Ana C. Alho et al. Blood 2016;127: ©2016 by American Society of Hematology

Reconstitution of CD4Tregs, CD4Tcons, and CD8 T cells according to cGVHD status 9 months after transplant. Ana C. Alho et al. Blood 2016;127: ©2016 by American Society of Hematology

Differentiation characteristics of CD4Tregs, CD4Tcons, and CD8 T cells associated with cGVHD. Ana C. Alho et al. Blood 2016;127: ©2016 by American Society of Hematology