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Non-CD34+ Cells, Especially CD8+ Cytotoxic T Cells and CD56+ Natural Killer Cells, Rather Than CD34 Cells, Predict Early Engraftment and Better Transplantation.

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Presentation on theme: "Non-CD34+ Cells, Especially CD8+ Cytotoxic T Cells and CD56+ Natural Killer Cells, Rather Than CD34 Cells, Predict Early Engraftment and Better Transplantation."— Presentation transcript:

1 Non-CD34+ Cells, Especially CD8+ Cytotoxic T Cells and CD56+ Natural Killer Cells, Rather Than CD34 Cells, Predict Early Engraftment and Better Transplantation Outcomes in Patients with Hematologic Malignancies after Allogeneic Peripheral Stem Cell Transplantation  Dong Hwan Kim, Dong Il Won, Nan Young Lee, Sang Kyun Sohn, Jang Soo Suh, Kyu Bo Lee  Biology of Blood and Marrow Transplantation  Volume 12, Issue 7, Pages (July 2006) DOI: /j.bbmt Copyright © 2006 American Society for Blood and Marrow Transplantation Terms and Conditions

2 Figure 1 Differences in engraftment kinetics for neutrophils according to transplant dose of (A) CD34+ cells, (B) CD56+ NK cells, and (C) CD8+ Tc cells. (A) There is no difference in neutrophil engraftment kinetics according to transplant CD34+ cell dose; (B, C) in contrast, there is faster neutrophil engraftment in patients who received a higher transplant dose of NK or Tc cells. Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2006 American Society for Blood and Marrow Transplantation Terms and Conditions

3 Figure 2 OS and NRM according to transplant dose of (A, B) CD34+ cells, (C, D) CD56+ NK cells, and (E, F) CD8+ Tc cells. (A, B) There is a small but nonsignificant trend toward improved survival outcome among patients who received a higher transplant dose of CD34+ cells. (C-F) Improved survival outcomes were apparent for some time among patients who received a higher transplant dose of NK or Tc cells. Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2006 American Society for Blood and Marrow Transplantation Terms and Conditions

4 Figure 3 Immune reconstitution of CD8+ Tc cells/NK cells with CD3+ T and CD4+ Th cells according to transplant dose of CD34+, CD8+ Tc, and CD56+ NK cells. The mean value is marked on each point. A higher transplant dose of NK cells was strongly associated with subsequently faster CD3+ T cell (P = .092) and CD56+ NK cell reconstitution between 3 months and 1 year after transplantation (P = .090). In addition, a higher transplant dose of Tc was strongly associated with a subsequently faster CD4+ Th cell recovery between 3 months and 1 year (P = .062). Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2006 American Society for Blood and Marrow Transplantation Terms and Conditions


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