Informatics Tools and Services Biomedical Informatics Core Tim Aro

Electronic Data Capture (e.g. REDCap) Cohort Discovery (i2b2 and new initiatives) Data Extracts – EMR (Cerner) and Billing System (IDX) Clinical Trial Management System (CTMS) support and training (OnCore) Research Collaboration Environment (Research Portal) Researcher Networking (VIVO) Honest Broker Services Research Subject Recruitment Informatics Tools and Services CCTR Biomedical Informatics Core Bioinformatics Tools/Services

Secure Web-based Database and Surveys Customizable – Intuitive UI or Data Dictionary Multi-site Studies – Data Access Groups Access Controls – User Rights Robust Intuitive Reports and Data Exports IRB Approved - Recommended Free to VCU/VCUHS Faculty, Staff, Students, Affiliates redcap.vcu.edu

i2b2 informatics for integrating biology & the bedside Developed at Harvard Partners Healthcare through a CTSA grant, i2b2 is a query tool that allows uses to search selected clinical and billing data from VCU Health. Cohort identification – Users may search a de-identified database, without IRB approval, to determine the existence of a set of patients meeting specified criteria. The data are presented as unique patient counts. This means a patient is counted exactly once if he/she ever met the criteria specified by the query.

SHRINE* Shared Health Research Informatics NEtwork i2b2 SHRINE allows institutions to share data while protecting patient privacy and providing researchers access to large sample sizes not easily available at any single institution. VCU / PSU Collaboration We are currently working towards sharing the following data between institutions: Demographics Visit Type Diagnosis codes (ICD-9) * Labs, Medications (future state ) Use Case: Crohn’s Disease - Penn State PhD candidate *Initiative in progress – Fall 2016 projected go-live

TriNetX* TriNetX is a federated clinical data network of providers and pharmaceutical companies used to enhance clinical trial design and accelerate trial site and patient recruitment. *Initiative in progress - Winter 2017 projected go-live Patient Recruitment made easier Better understand the target patient population Potential Sponsorship from pharmaceutical companies May Collaborate with other TriNetX members

Conduct a Simple Chart Review in Cerner Need Data? e.g. Find data on 500 potential subjects (just look ‘em up!)

BIC data request form is submitted (go.vcu.edu/bicrequest)go.vcu.edu/bicrequest Analyst meets with researcher Discuss overall project goals Review requested data elements Gather screen shots of requested data in source front-end Collect sample MRNs that have requested data Analyst researches source systems to find the appropriate data Cerner Millennium EMR GE Centricity (formerly IDX) Billing Philips OB TraceVue Other VCU or VCU Health System source systems Merge data provided by researcher and disparate sources Deliver identified or de-identified data extract to researcher Data Extraction CCTR Biomedical Informatics Core

Data Extraction Use Case: HCV Target CCTR Biomedical Informatics Core – Data Extract Use Case

OnCore at VCU – Enterprise Wide CTMS

Robert B. MouldenOnCore CTMS Mary M. O'ConnellOnCore Learn More About OnCore at VCU

go.vcu.edu/bicportal Research Portal – Collaboration Environment

VIVO - communitynetwork.vcu.edu

Honest Broker Services Collaboration with the Cancer Informatics Core IRB approved Honest Broker Protocol PI is Tamas Gal, PhD Provide De-Identified data – with surrogate IDs

Clinical Trial Recruitment Tools StudyFinder.cctr.vcu.edu Mobile App

Bioinformatics Tools and Services Making sense of the massive amounts of genomic data can be a daunting task. Bioinformatics utilizes computational tools to organize, analyze and store such data generated by the life sciences and health industry. The CCTR offers a range of bioinformatics and related services: Bioinformatics I and Bioinformatics II short courses Free consultations Assistance on project management and experimental design Grant/proposal and manuscript writing Data analysis, visualization and interpretation Long-term research support for funded grants

Request Informatics Services go.vcu.edu/bicrequest Need Help?

Team Members Directors Dr. Krys Cios and Dr. Jon DeShazo Key Individuals Shannon Bruffy - i2b2 Analyst Jun He - Oncore Administrator/Data Analyst Mike Tran – REDCap Administrator/Developer Sowmya Nadiminti – Infrastructure Analyst Brian Bush – Special Projects – IT Analyst Patrick Shi – REDCap Support Technician Bobby Moulden – OnCore Manager Amy Olex – Bioinformatics Tamas Gal – Cancer Informatics Core Mike Sarkissian – Enterprise Data Warehouse Architect

CCTR Informatics Tools and Services Important Links (w/login info) Request Assistance go.vcu.edu/bicrequest (no login) Tools REDCap:redcap.vcu.edu (eID) I2b2: go.vcu.edu/i2b2 (account needed) Portal:go.vcu.edu/bicportal (eID) Experts:communitynetwork.vcu.edu (no login) Recruit:studyfinder.cctr.vcu.edu (no login)