1. MUSC i2b2 Jean Craig, Biomedical Informatics
Signe Denmark, Office of Clinical Research
Katie Kirchoff, Biomedical Informatics

2. Learning Objectives What is i2b2? Data in i2b2
How to use i2b2: demonstration
How to gain access & i2b2 resources
Brief overview of other feasibility tools & consultation service

3. What is i2b2? Informatics for Integrating Biology & the Bedside
Analytic Query Tool
Open Source
i2b2.org
NIH-funded National Center for Biomedical Computing
Established in 2004
Based at Partners HealthCare System

4. What is i2b2?
Enables researchers to query clinical data for discovery research
Platform adopted by many national and international CTSA networks and healthcare centers
Data is structured to feed TriNetX

5. MUSC i2b2 Project Patient counts for feasibility
Limited data sets for analysis
De-identified patient and visit data
Dates of service

6. MUSC i2b2 Project
Populated from data stored in the Research Data Warehouse (RDW)
Data is currently updated monthly
TriNetX is a subset of the data available in MUSC i2b2

7. MUSC i2b2 Project

8. MUSC i2b2 Project – Data

9. MUSC i2b2 Demo
i2b2.musc.edu

10. MUSC i2b2
If query times out, can access in the menu Reload previously run queries Shared query library

11. How to gain access to i2b2
User management policy follows the same policy as the Research Query Tool
Who can access MUSC i2b2?
MUSC faculty and sponsored staff members have access
All non-faculty users must be sponsored by a MUSC faculty member;
completed Sponsorship
Access is granted within 1-2 business days.

12. i2b2 Resources RDW/MUSC i2b2 Data Dictionary i2b2 FAQ
i2b2 Plug-in Guide

13. Feasibility Tools & Consultation
Self-service tools for de-identified patient counts
Honest Broker services for identified data & de-identified queries
Need help navigating the self-service tools? SCTR provides free Self-Service Research Data & Feasibility consultations
Epic and MUSC CDW report builds for research
Queries related to regional and national data networks

15. SlicerDicer
This tool allows de-identified query access to all patients available in Epic (Ambulatory 5/2012, Emergency 11/2012, Inpatient 7/2014)

16. SlicerDicer Access Complete training in MyQuest:
Epic SlicerDicer for Research (25 mins)
Once you complete the training in MyQuest, Paul Powers to enable your access
Additional available training in MyQuest:
Epic RPT050 Overview of SlicerDicer (5 mins)
Epic RPT051 Creating Populations in SlicerDicer (5 mins)
Epic RPT052 Comparing Populations in SlicerDicer (10 mins)

17. TriNetX: Data-Driven Clinical Trial Design & Recruitment
Real world data network of providers and pharma
August 2016 Go live at MUSC Epic encounter data since 7/1/2014 currently populated in TriNetX

18. MUSC Self-Service Feasibility Tools
Which self-service tool do I choose?
MUSC Self-Service Feasibility Tools
MUSC i2b2
TriNetX (consult service)
Epic SlicerDicer
CDW Research Query tool
User friendly interface X
Requires MUSC Faculty sponsorship
Training Required
Provide aggregate counts
Query by demographics
Query by medication orders
Query by labs
Query by Diagnosis
Use Sequential Criteria
Data available only after 7/2014
Query on Cancer registry data
Query based on encounter location
Create a query to share with an honest broker for recruitment patient list
Export a de-identified limited data set

19. Which self-service tool do I choose?
Do you need to receive more than aggregate counts of patients?
Do you need information counts for MUSC patients only
(Includes MUSC, Greenville Health System, Palmetto Health, Spartanburg Regional Healthcare System)
HSSC i2b2
Do you need data prior to 2014
Do you need cancer registry data or to filter by procedures?
SlicerDicer
MUSC i2b2
Research Query Tool
Will you need to receive identifiable data?
Will you need data prior to 2014
MUSC I2B2
Research Data Request
Will you need data only on your own clinical patients?
Will you need data prior to 2014?
Will you need cancer registry data or need to filter by procedures?
Yes No No
Yes No
Yes No
Yes No
Yes
Yes No No
Yes
Create a key for requires training, No
Yes

20.
sctr.musc.edu

21. Data Preparatory to Research Requests
Can be requested without IRB approval HIPAA Privacy rule preparatory to Research Provision
45 CFR (i)(1)(ii) 
The following attestation much be agreed upon and adhered to with regards to the received data
Because you selected "Preparatory to Research requiring identifiers", you must agree that:
(A) Use or disclosure is sought solely to review protected health information as necessary to prepare a research protocol or for similar purposes preparatory to research;
(B) No protected health information is to be removed from the covered entity by the researcher in the course of the review; and
(C) The protected health information requested is the MINIMUM level necessary for assessment of the feasibility of this research project